Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection

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ID Serval
serval:BIB_3BA105C2A9B6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Production externe
Titre
Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection
Périodique
Nat Chem Biol
Auteur⸱e⸱s
Puri A. W., Broz P., Shen A., Monack D. M., Bogyo M.
ISSN
1552-4469 (Electronic)
ISSN-L
1552-4450
Statut éditorial
Publié
Date de publication
09/2012
Volume
8
Numéro
9
Pages
745-7
Langue
anglais
Notes
Puri, Aaron W
Broz, Petr
Shen, Aimee
Monack, Denise M
Bogyo, Matthew
eng
R01 EB005011/EB/NIBIB NIH HHS/
R01 AI089722/AI/NIAID NIH HHS/
R01EB005011/EB/NIBIB NIH HHS/
R21 AI088541/AI/NIAID NIH HHS/
R01AI088541/AI/NIAID NIH HHS/
K99 GM092934/GM/NIGMS NIH HHS/
R01 AI078947/AI/NIAID NIH HHS/
R01 AI095396/AI/NIAID NIH HHS/
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Nat Chem Biol. 2012 Sep;8(9):745-7. doi: 10.1038/nchembio.1023. Epub 2012 Jul 15.
Résumé
Here we report AWP28, an activity-based probe that can be used to biochemically monitor caspase-1 activation in response to proinflammatory stimuli. Using AWP28, we show that apoptosis is triggered upon Salmonella enterica var. Typhimurium infection in primary mouse bone marrow macrophages lacking caspase-1. Furthermore, we report that upon Salmonella infection, inflammasome-mediated caspase-1 activity is required to bypass apoptosis in favor of proinflammatory pyroptotic cell death.
Mots-clé
Animals, *Apoptosis, Caspase 1/*metabolism, Enzyme Activation, Macrophages/*cytology, Mice, Salmonella Infections/*enzymology/*pathology
DOI
10.1038/nchembio.1023
Pubmed
22797665
Création de la notice
25/10/2017 11:05
Dernière modification de la notice
20/01/2021 7:26
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