Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection

Details

Serval ID
serval:BIB_3BA105C2A9B6
Type
Article: article from journal or magazin.
Collection
Publications
Title
Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection
Journal
Nat Chem Biol
Author(s)
Puri A. W., Broz P., Shen A., Monack D. M., Bogyo M.
ISSN
1552-4469 (Electronic)
ISSN-L
1552-4450
Publication state
Published
Issued date
09/2012
Volume
8
Number
9
Pages
745-7
Language
english
Notes
Puri, Aaron W
Broz, Petr
Shen, Aimee
Monack, Denise M
Bogyo, Matthew
eng
R01 EB005011/EB/NIBIB NIH HHS/
R01 AI089722/AI/NIAID NIH HHS/
R01EB005011/EB/NIBIB NIH HHS/
R21 AI088541/AI/NIAID NIH HHS/
R01AI088541/AI/NIAID NIH HHS/
K99 GM092934/GM/NIGMS NIH HHS/
R01 AI078947/AI/NIAID NIH HHS/
R01 AI095396/AI/NIAID NIH HHS/
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Nat Chem Biol. 2012 Sep;8(9):745-7. doi: 10.1038/nchembio.1023. Epub 2012 Jul 15.
Abstract
Here we report AWP28, an activity-based probe that can be used to biochemically monitor caspase-1 activation in response to proinflammatory stimuli. Using AWP28, we show that apoptosis is triggered upon Salmonella enterica var. Typhimurium infection in primary mouse bone marrow macrophages lacking caspase-1. Furthermore, we report that upon Salmonella infection, inflammasome-mediated caspase-1 activity is required to bypass apoptosis in favor of proinflammatory pyroptotic cell death.
Keywords
Animals, *Apoptosis, Caspase 1/*metabolism, Enzyme Activation, Macrophages/*cytology, Mice, Salmonella Infections/*enzymology/*pathology
Pubmed
Create date
25/10/2017 10:05
Last modification date
20/01/2021 6:26
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