Metabolic effects of an increase of sympathetic activity in healthy humans
Détails
ID Serval
serval:BIB_3B99F3FE99D9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Metabolic effects of an increase of sympathetic activity in healthy humans
Périodique
International Journal of Obesity and Related Metabolic Disorders
ISSN
0307-0565 (Print)
Statut éditorial
Publié
Date de publication
06/1995
Volume
19
Numéro
6
Pages
419-22
Notes
Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun
Résumé
OBJECTIVE: To determine the metabolic effects of catecholamines released at sympathetic nerves ending in the postabsorptive and postprandial states. DESIGN: Sympathetic activity was acutely increased by lower body negative pressure (LBNP; -15 mmHg) on two occasions in a group of eight healthy volunteers: (1) in the postabsorptive state; and (2) after glucose ingestion. MEASUREMENTS: Plasma norepinephrine concentrations were determined by HPLC and energy expenditure and substrate oxidation rates were assessed with indirect calorimetry. RESULTS: After glucose, LBNP increased plasma norepinephrine by 27% and lipid oxidation by 72% and decreased glucose oxidation by 14%. Energy expenditure was not altered. In the postabsorptive state, LBNP increased plasma norepinephrine by 34%, but had no significant effect on energy or substrate metabolism. CONCLUSIONS: In healthy humans, LBNP-induced activation of the sympathetic nervous system decreases glucose oxidation and increases lipid oxidation after oral glucose, but does not quantitatively affect energy expenditure.
Mots-clé
Adult
Blood Glucose/analysis
Calorimetry, Indirect
Catecholamines/metabolism/*physiology
Chromatography, High Pressure Liquid
Eating/*physiology
Energy Metabolism/*physiology
Epinephrine/blood
Female
Glucose/metabolism
Humans
Lower Body Negative Pressure
Male
Norepinephrine/blood
Sympathetic Nervous System/metabolism/*physiology
Pubmed
Web of science
Création de la notice
24/01/2008 14:37
Dernière modification de la notice
20/08/2019 14:31