Metabolic effects of an increase of sympathetic activity in healthy humans

Details

Serval ID
serval:BIB_3B99F3FE99D9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Metabolic effects of an increase of sympathetic activity in healthy humans
Journal
International Journal of Obesity and Related Metabolic Disorders
Author(s)
Tappy  L., Girardet  K., Schwaller  N., Vollenweider  L., Jequier  E., Nicod  P., Scherrer  U.
ISSN
0307-0565 (Print)
Publication state
Published
Issued date
06/1995
Volume
19
Number
6
Pages
419-22
Notes
Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun
Abstract
OBJECTIVE: To determine the metabolic effects of catecholamines released at sympathetic nerves ending in the postabsorptive and postprandial states. DESIGN: Sympathetic activity was acutely increased by lower body negative pressure (LBNP; -15 mmHg) on two occasions in a group of eight healthy volunteers: (1) in the postabsorptive state; and (2) after glucose ingestion. MEASUREMENTS: Plasma norepinephrine concentrations were determined by HPLC and energy expenditure and substrate oxidation rates were assessed with indirect calorimetry. RESULTS: After glucose, LBNP increased plasma norepinephrine by 27% and lipid oxidation by 72% and decreased glucose oxidation by 14%. Energy expenditure was not altered. In the postabsorptive state, LBNP increased plasma norepinephrine by 34%, but had no significant effect on energy or substrate metabolism. CONCLUSIONS: In healthy humans, LBNP-induced activation of the sympathetic nervous system decreases glucose oxidation and increases lipid oxidation after oral glucose, but does not quantitatively affect energy expenditure.
Keywords
Adult Blood Glucose/analysis Calorimetry, Indirect Catecholamines/metabolism/*physiology Chromatography, High Pressure Liquid Eating/*physiology Energy Metabolism/*physiology Epinephrine/blood Female Glucose/metabolism Humans Lower Body Negative Pressure Male Norepinephrine/blood Sympathetic Nervous System/metabolism/*physiology
Pubmed
Web of science
Create date
24/01/2008 13:37
Last modification date
20/08/2019 13:31
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