The Vast Universe of T Cell Diversity: Subsets of Memory Cells and Their Differentiation.

Détails

ID Serval
serval:BIB_3B7AD728CB93
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The Vast Universe of T Cell Diversity: Subsets of Memory Cells and Their Differentiation.
Périodique
Methods in molecular biology
Auteur(s)
Jandus C., Usatorre A.M., Viganò S., Zhang L., Romero P.
ISSN
1940-6029 (Electronic)
ISSN-L
1064-3745
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
1514
Pages
1-17
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
The T cell receptor confers specificity for antigen recognition to T cells. By the first encounter with the cognate antigen, reactive T cells initiate a program of expansion and differentiation that will define not only the ultimate quantity of specific cells that will be generated, but more importantly their quality and functional heterogeneity. Recent achievements using mouse model infection systems have helped to shed light into the complex network of factors that dictate and sustain memory T cell differentiation, ranging from antigen load, TCR signal strength, metabolic fitness, transcriptional programs, and proliferative potential. The different models of memory T cell differentiation are discussed in this chapter, and key phenotypic and functional attributes of memory T cell subsets are presented, both for mouse and human cells. Therapeutic manipulation of memory T cell generation is expected to provide novel unique ways to optimize current immunotherapies, both in infection and cancer.

Mots-clé
Animals, Antigens/immunology, Cell Differentiation/genetics, Humans, Immunologic Memory, Lymphocyte Activation/immunology, Mice, Receptors, Antigen, T-Cell/immunology, T-Cell Antigen Receptor Specificity/immunology, T-Lymphocyte Subsets/immunology, Antigen, Differentiation, Memory, Subsets, T cell, TCR, Vaccine
Pubmed
Création de la notice
30/11/2016 19:40
Dernière modification de la notice
20/08/2019 14:31
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