The Vast Universe of T Cell Diversity: Subsets of Memory Cells and Their Differentiation.

Details

Serval ID
serval:BIB_3B7AD728CB93
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The Vast Universe of T Cell Diversity: Subsets of Memory Cells and Their Differentiation.
Journal
Methods in molecular biology
Author(s)
Jandus C., Usatorre A.M., Viganò S., Zhang L., Romero P.
ISSN
1940-6029 (Electronic)
ISSN-L
1064-3745
Publication state
Published
Issued date
2017
Peer-reviewed
Oui
Volume
1514
Pages
1-17
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
The T cell receptor confers specificity for antigen recognition to T cells. By the first encounter with the cognate antigen, reactive T cells initiate a program of expansion and differentiation that will define not only the ultimate quantity of specific cells that will be generated, but more importantly their quality and functional heterogeneity. Recent achievements using mouse model infection systems have helped to shed light into the complex network of factors that dictate and sustain memory T cell differentiation, ranging from antigen load, TCR signal strength, metabolic fitness, transcriptional programs, and proliferative potential. The different models of memory T cell differentiation are discussed in this chapter, and key phenotypic and functional attributes of memory T cell subsets are presented, both for mouse and human cells. Therapeutic manipulation of memory T cell generation is expected to provide novel unique ways to optimize current immunotherapies, both in infection and cancer.

Keywords
Animals, Antigens/immunology, Cell Differentiation/genetics, Humans, Immunologic Memory, Lymphocyte Activation/immunology, Mice, Receptors, Antigen, T-Cell/immunology, T-Cell Antigen Receptor Specificity/immunology, T-Lymphocyte Subsets/immunology, Antigen, Differentiation, Memory, Subsets, T cell, TCR, Vaccine
Pubmed
Create date
30/11/2016 18:40
Last modification date
20/08/2019 13:31
Usage data