Steroid hormone pulsing drives cyclic gene expression.
Détails
ID Serval
serval:BIB_3B2B3C0EA410
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Lettre (letter): communication adressée à l'éditeur.
Collection
Publications
Institution
Titre
Steroid hormone pulsing drives cyclic gene expression.
Périodique
Nature Cell Biology
ISSN
1476-4679[electronic]
Statut éditorial
Publié
Date de publication
2009
Volume
11
Numéro
9
Pages
1051-1053
Langue
anglais
Notes
Publication types: Comment ; News
Résumé
Transcriptional cycling of activated glucocorticoid receptor (GR) and ultradian glucocorticoid secretion are well established processes. Ultradian hormone release is now shown to result in pulsatile gene transcription through dynamic exchange of GR with the target-gene promoter and GR cycling through the chaperone machinery.
Mots-clé
Adrenal Cortex Hormones/blood, Adrenal Cortex Hormones/pharmacology, Animals, Gene Expression Regulation/drug effects, Humans, Mice, Models, Biological, Rats, Receptors, Glucocorticoid/metabolism, Response Elements/genetics, Transcription, Genetic/drug effects
Pubmed
Web of science
Création de la notice
08/10/2009 15:04
Dernière modification de la notice
20/08/2019 14:31
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