Steroid hormone pulsing drives cyclic gene expression.
Details
Serval ID
serval:BIB_3B2B3C0EA410
Type
Article: article from journal or magazin.
Publication sub-type
Letter (letter): Communication to the publisher.
Collection
Publications
Institution
Title
Steroid hormone pulsing drives cyclic gene expression.
Journal
Nature Cell Biology
ISSN
1476-4679[electronic]
Publication state
Published
Issued date
2009
Volume
11
Number
9
Pages
1051-1053
Language
english
Notes
Publication types: Comment ; News
Abstract
Transcriptional cycling of activated glucocorticoid receptor (GR) and ultradian glucocorticoid secretion are well established processes. Ultradian hormone release is now shown to result in pulsatile gene transcription through dynamic exchange of GR with the target-gene promoter and GR cycling through the chaperone machinery.
Keywords
Adrenal Cortex Hormones/blood, Adrenal Cortex Hormones/pharmacology, Animals, Gene Expression Regulation/drug effects, Humans, Mice, Models, Biological, Rats, Receptors, Glucocorticoid/metabolism, Response Elements/genetics, Transcription, Genetic/drug effects
Pubmed
Web of science
Create date
08/10/2009 14:04
Last modification date
20/08/2019 13:31
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