Diagnostic value of thyroglobulin assay in cervical lymph node fine-needle aspirations for metastatic differentiated thyroid cancer.

Détails

ID Serval
serval:BIB_3AE336F4305E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Diagnostic value of thyroglobulin assay in cervical lymph node fine-needle aspirations for metastatic differentiated thyroid cancer.
Périodique
Current Opinion In Oncology
Auteur(s)
Giovanella L., Bongiovanni M., Trimboli P.
ISSN
1531-703X (Electronic)
ISSN-L
1040-8746
Statut éditorial
Publié
Date de publication
2013
Volume
25
Numéro
1
Pages
6-13
Langue
anglais
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Résumé
PURPOSE OF REVIEW: Differentiated thyroid cancers (DTCs) have generally an indolent behavior. However, in a minority of these patients cervical metastasis at diagnosis or recurrence during follow-up may occur. Then, in suspicious neck lymph nodes fine-needle aspiration (FNA) is warranted. Thyroglobulin measurement in needle washout fluids (FNA-Tg) since its first description has been reported to increase the diagnostic accuracy of cytology in neck lymph nodes suspicious for metastatic DTC.
RECENT FINDINGS: Recent literature suggests that FNA-Tg can substitute conventional cytology and, in turn, simplifies clinical management of DTC patients. However, because of the large difference between these clinical studies, the data are sparse. Thus, neither procedures nor assay method for FNA-Tg have been standardized.
SUMMARY: FNA-Tg measurement is the more accurate tool to detect neck recurrences and metastases from DTC. Providing strict standardization of preanalytical and analytical phase, FNA-Tg may suffice to confirm or exclude neck DTC recurrence in patients with concurrent well differentiated papillary cancer type, suspicious neck ultrasound findings and increased serum thyroglobulin after thyroidectomy. On the contrary, FNA-Tg accuracy increases by adding cytological examination when FNA is performed before thyroidectomy, in patients with more aggressive histological types, and if low-undetectable serum thyroglobulin and/or positive serum antithyroglobulin antibodies occur.
Mots-clé
Biopsy, Fine-Needle, Female, Humans, Lymphatic Metastasis, Male, Neck, Neoplasm Recurrence, Local/diagnosis, Sensitivity and Specificity, Thyroglobulin/blood, Thyroid Neoplasms/diagnosis, Thyroid Neoplasms/pathology, Tumor Markers, Biological/blood
Pubmed
Web of science
Création de la notice
21/01/2015 17:06
Dernière modification de la notice
20/08/2019 14:30
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