Diagnostic value of thyroglobulin assay in cervical lymph node fine-needle aspirations for metastatic differentiated thyroid cancer.

Details

Serval ID
serval:BIB_3AE336F4305E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Diagnostic value of thyroglobulin assay in cervical lymph node fine-needle aspirations for metastatic differentiated thyroid cancer.
Journal
Current Opinion In Oncology
Author(s)
Giovanella L., Bongiovanni M., Trimboli P.
ISSN
1531-703X (Electronic)
ISSN-L
1040-8746
Publication state
Published
Issued date
2013
Volume
25
Number
1
Pages
6-13
Language
english
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Abstract
PURPOSE OF REVIEW: Differentiated thyroid cancers (DTCs) have generally an indolent behavior. However, in a minority of these patients cervical metastasis at diagnosis or recurrence during follow-up may occur. Then, in suspicious neck lymph nodes fine-needle aspiration (FNA) is warranted. Thyroglobulin measurement in needle washout fluids (FNA-Tg) since its first description has been reported to increase the diagnostic accuracy of cytology in neck lymph nodes suspicious for metastatic DTC.
RECENT FINDINGS: Recent literature suggests that FNA-Tg can substitute conventional cytology and, in turn, simplifies clinical management of DTC patients. However, because of the large difference between these clinical studies, the data are sparse. Thus, neither procedures nor assay method for FNA-Tg have been standardized.
SUMMARY: FNA-Tg measurement is the more accurate tool to detect neck recurrences and metastases from DTC. Providing strict standardization of preanalytical and analytical phase, FNA-Tg may suffice to confirm or exclude neck DTC recurrence in patients with concurrent well differentiated papillary cancer type, suspicious neck ultrasound findings and increased serum thyroglobulin after thyroidectomy. On the contrary, FNA-Tg accuracy increases by adding cytological examination when FNA is performed before thyroidectomy, in patients with more aggressive histological types, and if low-undetectable serum thyroglobulin and/or positive serum antithyroglobulin antibodies occur.
Keywords
Biopsy, Fine-Needle, Female, Humans, Lymphatic Metastasis, Male, Neck, Neoplasm Recurrence, Local/diagnosis, Sensitivity and Specificity, Thyroglobulin/blood, Thyroid Neoplasms/diagnosis, Thyroid Neoplasms/pathology, Tumor Markers, Biological/blood
Pubmed
Web of science
Create date
21/01/2015 16:06
Last modification date
20/08/2019 13:30
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