trans activation of the tumor necrosis factor alpha promoter by the human T-cell leukemia virus type I Tax1 protein
Détails
ID Serval
serval:BIB_39F7B2DB70D9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
trans activation of the tumor necrosis factor alpha promoter by the human T-cell leukemia virus type I Tax1 protein
Périodique
Journal of Virology
ISSN
0022-538X (Print)
Statut éditorial
Publié
Date de publication
10/1992
Volume
66
Numéro
10
Pages
6191-3
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct
Research Support, Non-U.S. Gov't --- Old month value: Oct
Résumé
In a cotransfection assay, the human T-cell leukemia virus type I Tax1 gene product specifically activated transcription from the mouse tumor necrosis factor alpha promoter. The activation patterns of 5' deletion mutants, artificial enhancer constructs, and point mutations in the promoter indicate that the major Tax1-responsive element is a site at position -655 which binds the NF-kappa B/rel and NF-GMa transcription factors.
Mots-clé
Animals
Base Sequence
Chloramphenicol O-Acetyltransferase/genetics
Enhancer Elements (Genetics)
Gene Products, tax/*metabolism
Mice
Molecular Sequence Data
Mutation
NF-kappa B/metabolism
Plasmids
*Promoter Regions (Genetics)
*Trans-Activation (Genetics)
Transfection
Tumor Necrosis Factor-alpha/*genetics
Pubmed
Web of science
Création de la notice
24/01/2008 16:39
Dernière modification de la notice
20/08/2019 14:29