trans activation of the tumor necrosis factor alpha promoter by the human T-cell leukemia virus type I Tax1 protein
Details
Serval ID
serval:BIB_39F7B2DB70D9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
trans activation of the tumor necrosis factor alpha promoter by the human T-cell leukemia virus type I Tax1 protein
Journal
Journal of Virology
ISSN
0022-538X (Print)
Publication state
Published
Issued date
10/1992
Volume
66
Number
10
Pages
6191-3
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct
Research Support, Non-U.S. Gov't --- Old month value: Oct
Abstract
In a cotransfection assay, the human T-cell leukemia virus type I Tax1 gene product specifically activated transcription from the mouse tumor necrosis factor alpha promoter. The activation patterns of 5' deletion mutants, artificial enhancer constructs, and point mutations in the promoter indicate that the major Tax1-responsive element is a site at position -655 which binds the NF-kappa B/rel and NF-GMa transcription factors.
Keywords
Animals
Base Sequence
Chloramphenicol O-Acetyltransferase/genetics
Enhancer Elements (Genetics)
Gene Products, tax/*metabolism
Mice
Molecular Sequence Data
Mutation
NF-kappa B/metabolism
Plasmids
*Promoter Regions (Genetics)
*Trans-Activation (Genetics)
Transfection
Tumor Necrosis Factor-alpha/*genetics
Pubmed
Web of science
Create date
24/01/2008 15:39
Last modification date
20/08/2019 13:29