Single and repeated dosing of the converting enzyme inhibitor perindopril to normal subjects

Détails

ID Serval
serval:BIB_38C87E64684D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Single and repeated dosing of the converting enzyme inhibitor perindopril to normal subjects
Périodique
Clinical Pharmacology and Therapeutics
Auteur(s)
Bussien  J. P., d'Amore  T. F., Perret  L., Porchet  M., Nussberger  J., Waeber  B., Brunner  H. R.
ISSN
0009-9236 (Print)
Statut éditorial
Publié
Date de publication
05/1986
Volume
39
Numéro
5
Pages
554-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May
Résumé
The new orally active angiotensin converting enzyme (ACE) inhibitor perindopril (S9490-3) was evaluated in 18 normotensive men. In three subjects the pressor response to exogenous angiotensin I was tested. A 8 mg oral dose reduced the pressor response by greater than 80%. Single oral perindopril doses of 2, 4, 8, and 16 mg were given to groups of five subjects each. Eight and 16 mg decreased plasma ACE activity within 4 hours to less than 10% of control; 72 hours later, plasma ACE activity was still reduced by at least 40%. Doses of 4 and 8 mg po once a day were then given for 8 days to two groups of six subjects. Four hours after the first and the last morning doses, plasma angiotensin II, aldosterone, and plasma ACE activity fell significantly, whereas blood angiotensin I and plasma renin activity rose. There was no evidence of drug accumulation. No significant change in blood pressure or heart rate was observed. Thus in normotensive subjects, perindopril seems an effective, orally active, long-lasting ACE inhibitor.
Mots-clé
Acetylcholinesterase/blood Administration, Oral Adult Aldosterone/blood Angiotensin I/blood Blood Pressure/drug effects Dose-Response Relationship, Drug Heart Rate/drug effects Humans Indoles/*pharmacology Male Perindopril Radioimmunoassay Renin/blood Renin-Angiotensin System/*drug effects
Pubmed
Web of science
Création de la notice
05/03/2008 17:40
Dernière modification de la notice
20/08/2019 14:28
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