Single and repeated dosing of the converting enzyme inhibitor perindopril to normal subjects

Details

Serval ID
serval:BIB_38C87E64684D
Type
Article: article from journal or magazin.
Collection
Publications
Title
Single and repeated dosing of the converting enzyme inhibitor perindopril to normal subjects
Journal
Clinical Pharmacology and Therapeutics
Author(s)
Bussien  J. P., d'Amore  T. F., Perret  L., Porchet  M., Nussberger  J., Waeber  B., Brunner  H. R.
ISSN
0009-9236 (Print)
Publication state
Published
Issued date
05/1986
Volume
39
Number
5
Pages
554-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May
Abstract
The new orally active angiotensin converting enzyme (ACE) inhibitor perindopril (S9490-3) was evaluated in 18 normotensive men. In three subjects the pressor response to exogenous angiotensin I was tested. A 8 mg oral dose reduced the pressor response by greater than 80%. Single oral perindopril doses of 2, 4, 8, and 16 mg were given to groups of five subjects each. Eight and 16 mg decreased plasma ACE activity within 4 hours to less than 10% of control; 72 hours later, plasma ACE activity was still reduced by at least 40%. Doses of 4 and 8 mg po once a day were then given for 8 days to two groups of six subjects. Four hours after the first and the last morning doses, plasma angiotensin II, aldosterone, and plasma ACE activity fell significantly, whereas blood angiotensin I and plasma renin activity rose. There was no evidence of drug accumulation. No significant change in blood pressure or heart rate was observed. Thus in normotensive subjects, perindopril seems an effective, orally active, long-lasting ACE inhibitor.
Keywords
Acetylcholinesterase/blood Administration, Oral Adult Aldosterone/blood Angiotensin I/blood Blood Pressure/drug effects Dose-Response Relationship, Drug Heart Rate/drug effects Humans Indoles/*pharmacology Male Perindopril Radioimmunoassay Renin/blood Renin-Angiotensin System/*drug effects
Pubmed
Web of science
Create date
05/03/2008 16:40
Last modification date
20/08/2019 13:28
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