Cell birth and death in childhood acute lymphoblastic leukaemia: how fast does the neoplastic cell clone expand?

Détails

ID Serval
serval:BIB_38B89E6F95A6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Cell birth and death in childhood acute lymphoblastic leukaemia: how fast does the neoplastic cell clone expand?
Périodique
British Journal of Haematology
Auteur(s)
Hirt  A., Leibundgut  K., Luthy  A. R., von der Weid  N., Wagner  H. P.
ISSN
0007-1048 (Print)
Statut éditorial
Publié
Date de publication
09/1997
Volume
98
Numéro
4
Pages
999-1001
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep
Résumé
In 23 children with untreated precursor B-cell acute lymphoblastic leukaemia (ALL), the daily growth rate of the malignant cell clone was calculated. Cell birth expanded the leukaemic cell clone an average 10-11% per day, programmed cell death or apoptosis reduced the leukaemic cell mass by some 4% per day. From these two variables a net increase in the size of the leukaemic cell population of 6.9+/-7.3% (range -1.2-27.3%) per day could be calculated. The daily growth rate correlated negatively with the logarithm of the duration of clinical symptoms before the diagnosis of ALL was established (r=-0.680; P=0.0004). A long history, especially in children with undefined bone pain and arthralgias, was associated with a very slow expansion of the neoplastic cell clone.
Mots-clé
Cell Death Cell Division Child Clone Cells/*pathology Humans Leukemia, Lymphocytic, Acute, L1/*pathology Leukemia, Pre-B-Cell/pathology Time Factors
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 11:35
Dernière modification de la notice
20/08/2019 14:28
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