Cell birth and death in childhood acute lymphoblastic leukaemia: how fast does the neoplastic cell clone expand?
Details
Serval ID
serval:BIB_38B89E6F95A6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cell birth and death in childhood acute lymphoblastic leukaemia: how fast does the neoplastic cell clone expand?
Journal
British Journal of Haematology
ISSN
0007-1048 (Print)
Publication state
Published
Issued date
09/1997
Volume
98
Number
4
Pages
999-1001
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep
Research Support, Non-U.S. Gov't --- Old month value: Sep
Abstract
In 23 children with untreated precursor B-cell acute lymphoblastic leukaemia (ALL), the daily growth rate of the malignant cell clone was calculated. Cell birth expanded the leukaemic cell clone an average 10-11% per day, programmed cell death or apoptosis reduced the leukaemic cell mass by some 4% per day. From these two variables a net increase in the size of the leukaemic cell population of 6.9+/-7.3% (range -1.2-27.3%) per day could be calculated. The daily growth rate correlated negatively with the logarithm of the duration of clinical symptoms before the diagnosis of ALL was established (r=-0.680; P=0.0004). A long history, especially in children with undefined bone pain and arthralgias, was associated with a very slow expansion of the neoplastic cell clone.
Keywords
Cell Death
Cell Division
Child
Clone Cells/*pathology
Humans
Leukemia, Lymphocytic, Acute, L1/*pathology
Leukemia, Pre-B-Cell/pathology
Time Factors
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 11:35
Last modification date
20/08/2019 14:28