Characterization of myelodysplastic syndromes progressing to acute lymphoblastic leukemia.

Détails

ID Serval
serval:BIB_387FEDC64B22
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Characterization of myelodysplastic syndromes progressing to acute lymphoblastic leukemia.
Périodique
Annals of hematology
Auteur(s)
Martins F., Kruszewski M., Scarpelli I., Schoumans J., Spertini O., Lübbert M., Blum S.
ISSN
1432-0584 (Electronic)
ISSN-L
0939-5555
Statut éditorial
Publié
Date de publication
01/2021
Peer-reviewed
Oui
Volume
100
Numéro
1
Pages
63-78
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Résumé
Myelodysplastic syndromes (MDS) are a heterogeneous group of diseases, with a variable probability of transformation into acute leukemia, which is, in the vast majority of cases, of myeloid lineage. Nevertheless, rare cases of acute lymphoblastic leukemia in patients with previously diagnosed MDS have been reported. We describe a series of 3 cases of MDS/CMML marked with evolution to acute lymphoblastic leukemia (ALL) and provide a comprehensive review of the 49 cases documented in the literature so far. These sporadic events have only been published as single-case reports or small series to date. Such atypical cases emphasize the possibility of major phenotypic switches arising at the leukemic stem cell (LSC) and/or early progenitor levels, as a consequence of epigenetic and genomic events driving these changes in the bone marrow niche.
Mots-clé
Aged, 80 and over, Disease Progression, Female, Humans, Male, Middle Aged, Myelodysplastic Syndromes/blood, Myelodysplastic Syndromes/diagnosis, Myelodysplastic Syndromes/genetics, Precursor Cell Lymphoblastic Leukemia-Lymphoma/blood, Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis, Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics, Acute lymphoblastic leukemia, Acute myeloid leukemia, Early progenitor, Hematopoietic stem cell, KTM2A, Leukemic stem cell, MLL, Mixed lineage leukemia, Myelodysplastic syndrome, Phenotype switch
Pubmed
Web of science
Création de la notice
06/07/2020 13:50
Dernière modification de la notice
02/03/2021 7:25
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