Characterization of myelodysplastic syndromes progressing to acute lymphoblastic leukemia.

Details

Serval ID
serval:BIB_387FEDC64B22
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Characterization of myelodysplastic syndromes progressing to acute lymphoblastic leukemia.
Journal
Annals of hematology
Author(s)
Martins F., Kruszewski M., Scarpelli I., Schoumans J., Spertini O., Lübbert M., Blum S.
ISSN
1432-0584 (Electronic)
ISSN-L
0939-5555
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Myelodysplastic syndromes (MDS) are a heterogeneous group of diseases, with a variable probability of transformation into acute leukemia, which is, in the vast majority of cases, of myeloid lineage. Nevertheless, rare cases of acute lymphoblastic leukemia in patients with previously diagnosed MDS have been reported. We describe a series of 3 cases of MDS/CMML marked with evolution to acute lymphoblastic leukemia (ALL) and provide a comprehensive review of the 49 cases documented in the literature so far. These sporadic events have only been published as single-case reports or small series to date. Such atypical cases emphasize the possibility of major phenotypic switches arising at the leukemic stem cell (LSC) and/or early progenitor levels, as a consequence of epigenetic and genomic events driving these changes in the bone marrow niche.
Keywords
Acute lymphoblastic leukemia, Acute myeloid leukemia, Early progenitor, Hematopoietic stem cell, KTM2A, Leukemic stem cell, MLL, Mixed lineage leukemia, Myelodysplastic syndrome, Phenotype switch
Pubmed
Web of science
Create date
06/07/2020 13:50
Last modification date
21/07/2020 6:26
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