Onychomycosis insensitive to systemic terbinafine and azole treatments reveals non-dermatophyte moulds as infectious agents.

Détails

ID Serval
serval:BIB_382F35C99528
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Onychomycosis insensitive to systemic terbinafine and azole treatments reveals non-dermatophyte moulds as infectious agents.
Périodique
Dermatology
Auteur⸱e⸱s
Baudraz-Rosselet Florence, Ruffieux Catherine, Lurati Massimo, Bontems Olympia, Monod Michel
ISSN
1421-9832[electronic], 1018-8665[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
220
Numéro
2
Pages
164-168
Langue
anglais
Résumé
BACKGROUND: Dermatophytes are the main cause of onychomycoses, but various non-dermatophyte filamentous fungi are often isolated from abnormal nails. OBJECTIVE: Our aim was the in situ identification of the fungal infectious agent in 8 cases of onychomycoses which could not be cured after systemic terbinafine and itraconazole treatment. METHODS: Fungal DNA was extracted from nail samples, and infectious fungi were identified by restriction fragment length polymorphism (RFLP) of amplified fungal ribosomal DNA using a previously described PCR/RFLP assay. RESULTS: PCR/RFLP identification of fungi in nails allows the identification of the infectious agent: Fusarium sp., Acremonium sp. and Aspergillus sp. were found as a sole infectious agent in 5, 2 and 1 cases, respectively. CONCLUSIONS: Fusarium spp. and other non-dermatophyte filamentous fungi are especially difficult to cure in onychomycoses utilising standard treatment with terbinafine and itraconazole. PCR fungal identification helps demonstrate the presence of moulds in order to prescribe alternative antifungal treatments.
Mots-clé
Trichophyton, Fusarium, Acremonium, Aspergillus, Onychomycosis, Fungi, Identification, Assay, Nail
Pubmed
Web of science
Création de la notice
29/03/2010 16:19
Dernière modification de la notice
20/08/2019 14:26
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