Brain energy metabolism and dopaminergic function in Huntington's disease measured in vivo using positron emission tomography.

Détails

ID Serval
serval:BIB_378C667E5351
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Brain energy metabolism and dopaminergic function in Huntington's disease measured in vivo using positron emission tomography.
Périodique
Movement Disorders
Auteur(s)
Leenders K.L., Frackowiak R.S., Quinn N., Marsden C.D.
ISSN
0885-3185 (Print)
ISSN-L
0885-3185
Statut éditorial
Publié
Date de publication
1986
Volume
1
Numéro
1
Pages
69-77
Langue
anglais
Notes
Publication types: Case Reports ; Journal ArticlePublication Status: ppublish
Résumé
A 48-year-old man with typical Huntington's disease was investigated with computed tomography (CT) and positron emission tomography. Regional cerebral blood flow, oxygen extraction, oxygen and glucose utilisation, L-Dopa uptake, and dopamine (D2) receptor binding were measured using several positron-labelled tracers. CT showed slight atrophy of the head of caudate but no cortical atrophy, although distinct frontal lobe dysfunction was present on psychometric testing. Oxygen and glucose metabolism and cerebral blood flow were decreased in the striata and to a lesser extent in frontal cortex. Cerebral blood flow was in the low normal range throughout the remainder of the brain. A normal metabolic ratio was found in all regions, since the changes in glucose utilisation paralleled those in oxygen consumption. The capacity of the striatum to store dopamine as assessed by L-[18F]-fluorodopa uptake was normal, but dopamine (D2) receptor binding was decreased when compared to normal subjects.
Mots-clé
Carbon Radioisotopes, Cerebral Cortex/metabolism, Cerebrovascular Circulation, Corpus Striatum/metabolism, Dihydroxyphenylalanine/metabolism, Fluorine Radioisotopes, Glucose/metabolism, Humans, Huntington Disease/metabolism, Male, Middle Aged, Oxygen/metabolism, Receptors, Dopamine/metabolism, Receptors, Dopamine D2, Spiperone/metabolism, Tomography, Emission-Computed, Tomography, X-Ray Computed
Pubmed
Création de la notice
08/10/2011 16:17
Dernière modification de la notice
20/08/2019 14:26
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