Brain energy metabolism and dopaminergic function in Huntington's disease measured in vivo using positron emission tomography.

Details

Serval ID
serval:BIB_378C667E5351
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Brain energy metabolism and dopaminergic function in Huntington's disease measured in vivo using positron emission tomography.
Journal
Movement Disorders
Author(s)
Leenders K.L., Frackowiak R.S., Quinn N., Marsden C.D.
ISSN
0885-3185 (Print)
ISSN-L
0885-3185
Publication state
Published
Issued date
1986
Volume
1
Number
1
Pages
69-77
Language
english
Notes
Publication types: Case Reports ; Journal ArticlePublication Status: ppublish
Abstract
A 48-year-old man with typical Huntington's disease was investigated with computed tomography (CT) and positron emission tomography. Regional cerebral blood flow, oxygen extraction, oxygen and glucose utilisation, L-Dopa uptake, and dopamine (D2) receptor binding were measured using several positron-labelled tracers. CT showed slight atrophy of the head of caudate but no cortical atrophy, although distinct frontal lobe dysfunction was present on psychometric testing. Oxygen and glucose metabolism and cerebral blood flow were decreased in the striata and to a lesser extent in frontal cortex. Cerebral blood flow was in the low normal range throughout the remainder of the brain. A normal metabolic ratio was found in all regions, since the changes in glucose utilisation paralleled those in oxygen consumption. The capacity of the striatum to store dopamine as assessed by L-[18F]-fluorodopa uptake was normal, but dopamine (D2) receptor binding was decreased when compared to normal subjects.
Keywords
Carbon Radioisotopes, Cerebral Cortex/metabolism, Cerebrovascular Circulation, Corpus Striatum/metabolism, Dihydroxyphenylalanine/metabolism, Fluorine Radioisotopes, Glucose/metabolism, Humans, Huntington Disease/metabolism, Male, Middle Aged, Oxygen/metabolism, Receptors, Dopamine/metabolism, Receptors, Dopamine D2, Spiperone/metabolism, Tomography, Emission-Computed, Tomography, X-Ray Computed
Pubmed
Create date
08/10/2011 15:17
Last modification date
20/08/2019 13:26
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