Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in ∼40% of patients.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_36E7457158FD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in ∼40% of patients.
Périodique
The Journal of experimental medicine
Auteur⸱e⸱s
Gervais A., Rovida F., Avanzini M.A., Croce S., Marchal A., Lin S.C., Ferrari A., Thorball C.W., Constant O., Le Voyer T., Philippot Q., Rosain J., Angelini M., Pérez Lorenzo M., Bizien L., Achille C., Trespidi F., Burdino E., Cassaniti I., Lilleri D., Fornara C., Sammartino J.C., Cereda D., Marrocu C., Piralla A., Valsecchi C., Ricagno S., Cogo P., Neth O., Marín-Cruz I., Pacenti M., Sinigaglia A., Trevisan M., Volpe A., Marzollo A., Conti F., Lazzarotto T., Pession A., Viale P., Fellay J., Ghirardello S., Aubart M., Ghisetti V., Aiuti A., Jouanguy E., Bastard P., Percivalle E., Baldanti F., Puel A., MacDonald M.R., Rice C.M., Rossini G., Murray K.O., Simonin Y., Nagy A., Barzon L., Abel L., Diamond M.S., Cobat A., Zhang S.Y., Casanova J.L., Borghesi A.
ISSN
1540-9538 (Electronic)
ISSN-L
0022-1007
Statut éditorial
Publié
Date de publication
04/09/2023
Peer-reviewed
Oui
Volume
220
Numéro
9
Pages
e20230661
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Mosquito-borne West Nile virus (WNV) infection is benign in most individuals but can cause encephalitis in <1% of infected individuals. We show that ∼35% of patients hospitalized for WNV disease (WNVD) in six independent cohorts from the EU and USA carry auto-Abs neutralizing IFN-α and/or -ω. The prevalence of these antibodies is highest in patients with encephalitis (∼40%), and that in individuals with silent WNV infection is as low as that in the general population. The odds ratios for WNVD in individuals with these auto-Abs relative to those without them in the general population range from 19.0 (95% CI 15.0-24.0, P value <10-15) for auto-Abs neutralizing only 100 pg/ml IFN-α and/or IFN-ω to 127.4 (CI 87.1-186.4, P value <10-15) for auto-Abs neutralizing both IFN-α and IFN-ω at a concentration of 10 ng/ml. These antibodies block the protective effect of IFN-α in Vero cells infected with WNV in vitro. Auto-Abs neutralizing IFN-α and/or IFN-ω underlie ∼40% of cases of WNV encephalitis.
Mots-clé
Animals, Chlorocebus aethiops, Humans, West Nile Fever, West Nile virus, Vero Cells, Autoantibodies, Antibodies, Viral, Interferon Type I, Interferon-alpha
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/06/2023 11:11
Dernière modification de la notice
08/08/2024 6:31
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