Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in ∼40% of patients.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_36E7457158FD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in ∼40% of patients.
Journal
The Journal of experimental medicine
Author(s)
Gervais A., Rovida F., Avanzini M.A., Croce S., Marchal A., Lin S.C., Ferrari A., Thorball C.W., Constant O., Le Voyer T., Philippot Q., Rosain J., Angelini M., Pérez Lorenzo M., Bizien L., Achille C., Trespidi F., Burdino E., Cassaniti I., Lilleri D., Fornara C., Sammartino J.C., Cereda D., Marrocu C., Piralla A., Valsecchi C., Ricagno S., Cogo P., Neth O., Marín-Cruz I., Pacenti M., Sinigaglia A., Trevisan M., Volpe A., Marzollo A., Conti F., Lazzarotto T., Pession A., Viale P., Fellay J., Ghirardello S., Aubart M., Ghisetti V., Aiuti A., Jouanguy E., Bastard P., Percivalle E., Baldanti F., Puel A., MacDonald M.R., Rice C.M., Rossini G., Murray K.O., Simonin Y., Nagy A., Barzon L., Abel L., Diamond M.S., Cobat A., Zhang S.Y., Casanova J.L., Borghesi A.
ISSN
1540-9538 (Electronic)
ISSN-L
0022-1007
Publication state
Published
Issued date
04/09/2023
Peer-reviewed
Oui
Volume
220
Number
9
Pages
e20230661
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Mosquito-borne West Nile virus (WNV) infection is benign in most individuals but can cause encephalitis in <1% of infected individuals. We show that ∼35% of patients hospitalized for WNV disease (WNVD) in six independent cohorts from the EU and USA carry auto-Abs neutralizing IFN-α and/or -ω. The prevalence of these antibodies is highest in patients with encephalitis (∼40%), and that in individuals with silent WNV infection is as low as that in the general population. The odds ratios for WNVD in individuals with these auto-Abs relative to those without them in the general population range from 19.0 (95% CI 15.0-24.0, P value <10-15) for auto-Abs neutralizing only 100 pg/ml IFN-α and/or IFN-ω to 127.4 (CI 87.1-186.4, P value <10-15) for auto-Abs neutralizing both IFN-α and IFN-ω at a concentration of 10 ng/ml. These antibodies block the protective effect of IFN-α in Vero cells infected with WNV in vitro. Auto-Abs neutralizing IFN-α and/or IFN-ω underlie ∼40% of cases of WNV encephalitis.
Keywords
Animals, Chlorocebus aethiops, Humans, West Nile Fever, West Nile virus, Vero Cells, Autoantibodies, Antibodies, Viral, Interferon Type I, Interferon-alpha
Pubmed
Web of science
Open Access
Yes
Create date
26/06/2023 11:11
Last modification date
08/08/2024 6:31
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