2. La triade de Widal (asthme-polypose nasale-intolérance à l'aspirine): une anomalie du métabolisme inflammatoire [Widal triad (Asthma-Nasal polyposis-aspirin intolerance): an inflammatory metabolism abnormality]

Détails

ID Serval
serval:BIB_36726
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
2. La triade de Widal (asthme-polypose nasale-intolérance à l'aspirine): une anomalie du métabolisme inflammatoire [Widal triad (Asthma-Nasal polyposis-aspirin intolerance): an inflammatory metabolism abnormality]
Périodique
Revue médicale suisse
Auteur(s)
Leimgruber A.
ISSN
1660-9379
Statut éditorial
Publié
Date de publication
2005
Volume
1
Numéro
1
Pages
15-8
Langue
français
Notes
Publication types: English Abstract ; Journal Article - Publication Status: ppublish
Résumé
Widal disease is characterized by symptomatic triad of aspirin intolerance, nasal polyposis and asthma. This disease is closely linked to abnormalities of the arachidonic acid metabolism. Partly of genetic origin, these anomalies are also related to the immune system function and probably to age. These factors induce an increase of cysleukotriene synthetase enzyme, and consequently an overproduction of cysleukotrienes that have both proinflammatory and bronchoconstrictive effects. In recent years, encouraging results were obtained with anti-leukotrienes, especially when they are associated with topic corticosteroids. Finally, numerous research that attempt to reach a better understanding of arachidonic acid metabolism are underway, which enables us to hope for future therapeutic advances.
Mots-clé
Aspirin, Asthma, Drug Hypersensitivity, Humans, Metabolic Diseases, Nasal Polyps
Pubmed
Création de la notice
19/11/2007 12:34
Dernière modification de la notice
20/08/2019 13:24
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