2. La triade de Widal (asthme-polypose nasale-intolérance à l'aspirine): une anomalie du métabolisme inflammatoire [Widal triad (Asthma-Nasal polyposis-aspirin intolerance): an inflammatory metabolism abnormality]

Details

Serval ID
serval:BIB_36726
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
2. La triade de Widal (asthme-polypose nasale-intolérance à l'aspirine): une anomalie du métabolisme inflammatoire [Widal triad (Asthma-Nasal polyposis-aspirin intolerance): an inflammatory metabolism abnormality]
Journal
Revue médicale suisse
Author(s)
Leimgruber A.
ISSN
1660-9379
Publication state
Published
Issued date
2005
Volume
1
Number
1
Pages
15-8
Language
french
Notes
Publication types: English Abstract ; Journal Article - Publication Status: ppublish
Abstract
Widal disease is characterized by symptomatic triad of aspirin intolerance, nasal polyposis and asthma. This disease is closely linked to abnormalities of the arachidonic acid metabolism. Partly of genetic origin, these anomalies are also related to the immune system function and probably to age. These factors induce an increase of cysleukotriene synthetase enzyme, and consequently an overproduction of cysleukotrienes that have both proinflammatory and bronchoconstrictive effects. In recent years, encouraging results were obtained with anti-leukotrienes, especially when they are associated with topic corticosteroids. Finally, numerous research that attempt to reach a better understanding of arachidonic acid metabolism are underway, which enables us to hope for future therapeutic advances.
Keywords
Aspirin, Asthma, Drug Hypersensitivity, Humans, Metabolic Diseases, Nasal Polyps
Pubmed
Create date
19/11/2007 12:34
Last modification date
20/08/2019 13:24
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