L'hyperthermie maligne. [Malignant hyperthermia]

Détails

ID Serval
serval:BIB_35741304BD59
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
L'hyperthermie maligne. [Malignant hyperthermia]
Périodique
Revue Médicale de la Suisse Romande
Auteur⸱e⸱s
Chastonay  P., Bracco  D., Freymond  D., Ravussin  P.
ISSN
0035-3655
Statut éditorial
Publié
Date de publication
03/1999
Volume
119
Numéro
3
Pages
191-202
Notes
Case Reports
English Abstract
Journal Article
Review --- Old month value: Mar
Résumé
Malignant hyperthermia is a serious anesthetic complication, presenting with various manifestations, with high mortality and morbidity. There are several incomplete and abortive forms, and the clinicians must be aware of the possibility of malignant hyperthermia, and recognize the first signs of the hyperthermic crisis hyperthermia, hypermetabolism and muscular rigidity. Screening is performed by in vitro contracture testing on a muscular biopsy. Treatment is based on discontinuation of triggering agents and dantrolene administration, as well as supportive care. Cellular investigations demonstrate that the malignant hyperthermia crisis presents as an intracellular flooding with calcium, leading to an abnormal muscular contracture. Several mutations in particular involving the ryanodine receptor gene have been linked to malignant hyperthermia.
Mots-clé
Biopsy Child, Preschool Dantrolene/therapeutic use Disease Models, Animal Humans Male Malignant Hyperthermia/*diagnosis/etiology/metabolism/*therapy Mass Screening Muscle Relaxants, Central/therapeutic use Practice Guidelines as Topic Risk Factors Severity of Illness Index
Pubmed
Création de la notice
17/01/2008 16:19
Dernière modification de la notice
20/08/2019 13:22
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