L'hyperthermie maligne. [Malignant hyperthermia]

Details

Serval ID
serval:BIB_35741304BD59
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
L'hyperthermie maligne. [Malignant hyperthermia]
Journal
Revue Médicale de la Suisse Romande
Author(s)
Chastonay  P., Bracco  D., Freymond  D., Ravussin  P.
ISSN
0035-3655
Publication state
Published
Issued date
03/1999
Volume
119
Number
3
Pages
191-202
Notes
Case Reports
English Abstract
Journal Article
Review --- Old month value: Mar
Abstract
Malignant hyperthermia is a serious anesthetic complication, presenting with various manifestations, with high mortality and morbidity. There are several incomplete and abortive forms, and the clinicians must be aware of the possibility of malignant hyperthermia, and recognize the first signs of the hyperthermic crisis hyperthermia, hypermetabolism and muscular rigidity. Screening is performed by in vitro contracture testing on a muscular biopsy. Treatment is based on discontinuation of triggering agents and dantrolene administration, as well as supportive care. Cellular investigations demonstrate that the malignant hyperthermia crisis presents as an intracellular flooding with calcium, leading to an abnormal muscular contracture. Several mutations in particular involving the ryanodine receptor gene have been linked to malignant hyperthermia.
Keywords
Biopsy Child, Preschool Dantrolene/therapeutic use Disease Models, Animal Humans Male Malignant Hyperthermia/*diagnosis/etiology/metabolism/*therapy Mass Screening Muscle Relaxants, Central/therapeutic use Practice Guidelines as Topic Risk Factors Severity of Illness Index
Pubmed
Create date
17/01/2008 16:19
Last modification date
20/08/2019 13:22
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