Invasion of the peripheral nervous systems of adult mice by the CVS strain of rabies virus and its avirulent derivative AvO1.

Détails

ID Serval
serval:BIB_35485ED7CFED
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Invasion of the peripheral nervous systems of adult mice by the CVS strain of rabies virus and its avirulent derivative AvO1.
Périodique
Journal of Virology
Auteur(s)
Coulon P., Derbin C., Kucera P., Lafay F., Prehaud C., Flamand A.
ISSN
0022-538X (Print)
ISSN-L
0022-538X
Statut éditorial
Publié
Date de publication
1989
Peer-reviewed
Oui
Volume
63
Numéro
8
Pages
3550-3554
Langue
anglais
Résumé
The penetration of the CVS strain of rabies virus and its avirulent derivative AvO1 into peripheral neurons was investigated after intramuscular inoculation into the forelimbs of adult mice. It was found that CVS directly penetrates both the sensitive and motor routes with equal efficiency, without prior multiplication in muscle cells. Infected neurons became detectable 18 h after infection. The second cycle of infection occurred within 2 days, and at day 3 there was a massive invasion of the spinal cord and sensory ganglia. In sensory ganglia, where it was possible to identify cell outlines, it was evident that the infection did not proceed directly from cell body to cell body. The avirulent strain AvO1 penetrated motor and sensory neurons with the same efficiency as CVS. Restriction of viral propagation was observed from the second and third cycles onwards. No further development of the infection could be seen after day 3, and by that time the lysis of primarily infected neurons seemed to occur.

Mots-clé
Animals, Fluorescent Antibody Technique, Ganglia, Spinal/microbiology, Mice, Motor Neurons/microbiology, Neurons/microbiology, Neurons, Afferent/microbiology, Peripheral Nerves/microbiology, Rabies/etiology, Rabies/microbiology, Rabies virus/physiology, Spinal Cord/microbiology
Pubmed
Web of science
Création de la notice
16/01/2018 15:08
Dernière modification de la notice
20/08/2019 14:22
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