Invasion of the peripheral nervous systems of adult mice by the CVS strain of rabies virus and its avirulent derivative AvO1.

Details

Serval ID
serval:BIB_35485ED7CFED
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Invasion of the peripheral nervous systems of adult mice by the CVS strain of rabies virus and its avirulent derivative AvO1.
Journal
Journal of Virology
Author(s)
Coulon P., Derbin C., Kucera P., Lafay F., Prehaud C., Flamand A.
ISSN
0022-538X (Print)
ISSN-L
0022-538X
Publication state
Published
Issued date
1989
Peer-reviewed
Oui
Volume
63
Number
8
Pages
3550-3554
Language
english
Abstract
The penetration of the CVS strain of rabies virus and its avirulent derivative AvO1 into peripheral neurons was investigated after intramuscular inoculation into the forelimbs of adult mice. It was found that CVS directly penetrates both the sensitive and motor routes with equal efficiency, without prior multiplication in muscle cells. Infected neurons became detectable 18 h after infection. The second cycle of infection occurred within 2 days, and at day 3 there was a massive invasion of the spinal cord and sensory ganglia. In sensory ganglia, where it was possible to identify cell outlines, it was evident that the infection did not proceed directly from cell body to cell body. The avirulent strain AvO1 penetrated motor and sensory neurons with the same efficiency as CVS. Restriction of viral propagation was observed from the second and third cycles onwards. No further development of the infection could be seen after day 3, and by that time the lysis of primarily infected neurons seemed to occur.

Keywords
Animals, Fluorescent Antibody Technique, Ganglia, Spinal/microbiology, Mice, Motor Neurons/microbiology, Neurons/microbiology, Neurons, Afferent/microbiology, Peripheral Nerves/microbiology, Rabies/etiology, Rabies/microbiology, Rabies virus/physiology, Spinal Cord/microbiology
Pubmed
Web of science
Create date
16/01/2018 14:08
Last modification date
20/08/2019 13:22
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