The evolution in the use of MIBG scintigraphy in pheochromocytomas and paragangliomas.

Détails

ID Serval
serval:BIB_351F3905DBD3
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The evolution in the use of MIBG scintigraphy in pheochromocytomas and paragangliomas.
Périodique
Hormones
Auteur(s)
Rufini V., Treglia G., Perotti G., Giordano A.
ISSN
1109-3099 (Print)
ISSN-L
1109-3099
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
12
Numéro
1
Pages
58-68
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Radioiodinated metaiodobenzylguanidine (MIBG) was developed in the late 1970's, at the Michigan University Medical Center, for imaging of the adrenal medulla and its diseases. Soon after, MIBG was shown to depict a wide range of tumors of neural crest origin other than pheochromocytomas/paragangliomas (Pheo/PGL) with the result that its use rapidly spread to many countries. After more than 30 years of clinical application, MIBG continues to be the most widespread radiopharmaceutical for the functional imaging of Pheo/PGL in spite of the emergent role of PET agents for detection of these tumors. In this paper we review the evolution in the use of MIBG over more than 30 years of experimental and clinical applications, with particular focus on the uptake mechanisms, pharmacokinetics, biodistribution and drug interaction as well as on clinical studies in Pheo/PGL also in comparison to other gamma-emitters tracers and PET radiopharmaceuticals.

Mots-clé
3-Iodobenzylguanidine/adverse effects, 3-Iodobenzylguanidine/pharmacokinetics, Adrenal Gland Neoplasms/diagnostic imaging, Adrenal Gland Neoplasms/metabolism, Animals, Drug Interactions, Humans, Paraganglioma/diagnostic imaging, Paraganglioma/metabolism, Pheochromocytoma/diagnostic imaging, Pheochromocytoma/metabolism, Positron-Emission Tomography, Predictive Value of Tests, Radiopharmaceuticals/adverse effects, Radiopharmaceuticals/pharmacokinetics, Tissue Distribution, Tomography, Emission-Computed/methods, Tomography, Emission-Computed, Single-Photon
Pubmed
Web of science
Création de la notice
20/08/2017 22:10
Dernière modification de la notice
20/08/2019 14:22
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