The evolution in the use of MIBG scintigraphy in pheochromocytomas and paragangliomas.

Details

Serval ID
serval:BIB_351F3905DBD3
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
The evolution in the use of MIBG scintigraphy in pheochromocytomas and paragangliomas.
Journal
Hormones
Author(s)
Rufini V., Treglia G., Perotti G., Giordano A.
ISSN
1109-3099 (Print)
ISSN-L
1109-3099
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
12
Number
1
Pages
58-68
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Radioiodinated metaiodobenzylguanidine (MIBG) was developed in the late 1970's, at the Michigan University Medical Center, for imaging of the adrenal medulla and its diseases. Soon after, MIBG was shown to depict a wide range of tumors of neural crest origin other than pheochromocytomas/paragangliomas (Pheo/PGL) with the result that its use rapidly spread to many countries. After more than 30 years of clinical application, MIBG continues to be the most widespread radiopharmaceutical for the functional imaging of Pheo/PGL in spite of the emergent role of PET agents for detection of these tumors. In this paper we review the evolution in the use of MIBG over more than 30 years of experimental and clinical applications, with particular focus on the uptake mechanisms, pharmacokinetics, biodistribution and drug interaction as well as on clinical studies in Pheo/PGL also in comparison to other gamma-emitters tracers and PET radiopharmaceuticals.

Keywords
3-Iodobenzylguanidine/adverse effects, 3-Iodobenzylguanidine/pharmacokinetics, Adrenal Gland Neoplasms/diagnostic imaging, Adrenal Gland Neoplasms/metabolism, Animals, Drug Interactions, Humans, Paraganglioma/diagnostic imaging, Paraganglioma/metabolism, Pheochromocytoma/diagnostic imaging, Pheochromocytoma/metabolism, Positron-Emission Tomography, Predictive Value of Tests, Radiopharmaceuticals/adverse effects, Radiopharmaceuticals/pharmacokinetics, Tissue Distribution, Tomography, Emission-Computed/methods, Tomography, Emission-Computed, Single-Photon
Pubmed
Web of science
Create date
20/08/2017 21:10
Last modification date
20/08/2019 13:22
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