Spinal Cord Injury as a Model of Bone-Muscle Interactions: Therapeutic Implications From in vitro and in vivo Studies.

Détails

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Etat: Public
Version: de l'auteur
Licence: CC BY 4.0
ID Serval
serval:BIB_3475D9E3E9AB
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Spinal Cord Injury as a Model of Bone-Muscle Interactions: Therapeutic Implications From in vitro and in vivo Studies.
Périodique
Frontiers in endocrinology
Auteur(s)
Invernizzi M., de Sire A., Renò F., Cisari C., Runza L., Baricich A., Carda S., Fusco N.
ISSN
1664-2392 (Print)
ISSN-L
1664-2392
Statut éditorial
Publié
Date de publication
15/04/2020
Peer-reviewed
Oui
Volume
11
Pages
204
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Résumé
Spinal cord injuries (SCIs) represent a variety of conditions related to the damage of the spinal cord with consequent musculoskeletal repercussions. The bone and muscle tissues share several catabolic pathways that lead to variable degrees of disability in SCI patients. In this review article, we provide a comprehensive characterization of the available treatment options targeting the skeleton and the bone in the setting of SCI. Among the pharmacological intervention, bisphosphonates, anti-sclerostin monoclonal antibodies, hydrogen sulfide, parathyroid hormone, and RANKL pathway inhibitors represent valuable options for treating bone alterations. Loss phenomena at the level of the muscle can be counteracted with testosterone, anabolic-androgenic steroids, and selective androgen receptor modulators. Exercise and physical therapy are valuable strategies to increase bone and muscle mass. Nutritional interventions could enhance SCI treatment, particularly in the setting of synergistic and multidisciplinary interventions, but there are no specific guidelines available to date. The development of multidisciplinary recommendations is required for a proper clinical management of SCI patients.
Mots-clé
bone, bone loss, muscle, osteoporosis, rehabilitation, sarcopenia, spinal cord injury
Pubmed
Web of science
Open Access
Oui
Création de la notice
02/05/2020 13:32
Dernière modification de la notice
15/07/2020 5:26
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