Spinal Cord Injury as a Model of Bone-Muscle Interactions: Therapeutic Implications From in vitro and in vivo Studies.

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State: Public
Version: author
License: CC BY 4.0
Serval ID
serval:BIB_3475D9E3E9AB
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Spinal Cord Injury as a Model of Bone-Muscle Interactions: Therapeutic Implications From in vitro and in vivo Studies.
Journal
Frontiers in endocrinology
Author(s)
Invernizzi M., de Sire A., Renò F., Cisari C., Runza L., Baricich A., Carda S., Fusco N.
ISSN
1664-2392 (Print)
ISSN-L
1664-2392
Publication state
Published
Issued date
15/04/2020
Peer-reviewed
Oui
Volume
11
Pages
204
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Spinal cord injuries (SCIs) represent a variety of conditions related to the damage of the spinal cord with consequent musculoskeletal repercussions. The bone and muscle tissues share several catabolic pathways that lead to variable degrees of disability in SCI patients. In this review article, we provide a comprehensive characterization of the available treatment options targeting the skeleton and the bone in the setting of SCI. Among the pharmacological intervention, bisphosphonates, anti-sclerostin monoclonal antibodies, hydrogen sulfide, parathyroid hormone, and RANKL pathway inhibitors represent valuable options for treating bone alterations. Loss phenomena at the level of the muscle can be counteracted with testosterone, anabolic-androgenic steroids, and selective androgen receptor modulators. Exercise and physical therapy are valuable strategies to increase bone and muscle mass. Nutritional interventions could enhance SCI treatment, particularly in the setting of synergistic and multidisciplinary interventions, but there are no specific guidelines available to date. The development of multidisciplinary recommendations is required for a proper clinical management of SCI patients.
Keywords
bone, bone loss, muscle, osteoporosis, rehabilitation, sarcopenia, spinal cord injury
Pubmed
Web of science
Open Access
Yes
Create date
02/05/2020 13:32
Last modification date
15/07/2020 5:26
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