Keratoacanthoma: A distinct entity?

Détails

ID Serval
serval:BIB_3432B14CE2E7
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Keratoacanthoma: A distinct entity?
Périodique
Experimental Dermatology
Auteur(s)
Gleich T., Chiticariu E., Huber M., Hohl D.
ISSN
1600-0625 (Electronic)
ISSN-L
0906-6705
Statut éditorial
Publié
Date de publication
2015
Langue
anglais
Notes
Publication types: < ; ARTICLE
Publication Status: aheadofprint
Résumé
Keratoacanthoma (KA) are common but exceptional benign tumors, often appearing on sun-exposed areas of light skinned people and showing spontaneous resolution. The goal of this study was to review existing literature, to point out the etiologic complexity of KA biology and to answer the controversial debate if or not KA is a distinct entity or a variant of squamous cell carcinoma (SCC). Relying on recent results, we highlight that KA is an individual lesion with a unique molecular signature caused by alterations in the TGFβ signaling pathway. These recent findings will help to understand the nature of KA and to develop new reliable diagnostic tools, simplifying the discrimination of the histologically similar KA and SCC. This article is protected by copyright. All rights reserved.
Mots-clé
keratoacanthoma, paradoxical activation, squamous cell carcinoma, TGFbeta, tumor
Pubmed
Open Access
Oui
Création de la notice
04/01/2016 11:48
Dernière modification de la notice
16/07/2020 8:43
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