Keratoacanthoma: A distinct entity?

Details

Serval ID
serval:BIB_3432B14CE2E7
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Keratoacanthoma: A distinct entity?
Journal
Experimental Dermatology
Author(s)
Gleich T., Chiticariu E., Huber M., Hohl D.
ISSN
1600-0625 (Electronic)
ISSN-L
0906-6705
Publication state
Published
Issued date
2015
Language
english
Notes
Publication types: < ; ARTICLE
Publication Status: aheadofprint
Abstract
Keratoacanthoma (KA) are common but exceptional benign tumors, often appearing on sun-exposed areas of light skinned people and showing spontaneous resolution. The goal of this study was to review existing literature, to point out the etiologic complexity of KA biology and to answer the controversial debate if or not KA is a distinct entity or a variant of squamous cell carcinoma (SCC). Relying on recent results, we highlight that KA is an individual lesion with a unique molecular signature caused by alterations in the TGFβ signaling pathway. These recent findings will help to understand the nature of KA and to develop new reliable diagnostic tools, simplifying the discrimination of the histologically similar KA and SCC. This article is protected by copyright. All rights reserved.
Keywords
keratoacanthoma, paradoxical activation, squamous cell carcinoma, TGFbeta, tumor
Pubmed
Open Access
Yes
Create date
04/01/2016 11:48
Last modification date
16/07/2020 8:43
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