Tolerance study of ceftriaxone compared with amoxicillin in patients with pneumonia
Détails
ID Serval
serval:BIB_33400AD96955
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Tolerance study of ceftriaxone compared with amoxicillin in patients with pneumonia
Périodique
American Journal of Medicine
ISSN
0002-9343
Statut éditorial
Publié
Date de publication
10/1984
Peer-reviewed
Oui
Volume
77
Numéro
4C
Pages
54-8
Notes
Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial --- Old month value: Oct 19
Comparative Study
Journal Article
Randomized Controlled Trial --- Old month value: Oct 19
Résumé
The safety of ceftriaxone was compared with that of amoxicillin in a randomized study of 91 patients with community-acquired pneumonia. The origin of infection was similar in the two groups. It was proven or probable Streptococcus pneumoniae in 50 percent of the patients and remained uncertain in 40 percent. Ninety percent of the patients who received ceftriaxone were clinically cured compared with 69 percent of those given amoxicillin (p less than 0.05). However, this difference was not apparent among the patients with proven or probable pneumococcal pneumonia. No severe clinical side effects were observed. Cutaneous reactions were more prevalent in the amoxicillin group, whereas mild diarrhea and mucosal candidiasis were more frequent in the ceftriaxone group. Reversible neutropenia was observed in two patients treated with ceftriaxone and none of those treated with amoxicillin.
Mots-clé
Adult
Aged
Amoxicillin/*adverse effects
Cefotaxime/adverse effects/*analogs & derivatives
Ceftriaxone
Female
Humans
Male
Middle Aged
Neutropenia/chemically induced
Penicillins/adverse effects
Pneumococcal Infections/drug therapy
Pneumonia/*drug therapy/etiology
Pubmed
Web of science
Création de la notice
19/01/2008 19:12
Dernière modification de la notice
20/08/2019 14:19