Tolerance study of ceftriaxone compared with amoxicillin in patients with pneumonia

Details

Serval ID
serval:BIB_33400AD96955
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Tolerance study of ceftriaxone compared with amoxicillin in patients with pneumonia
Journal
American Journal of Medicine
Author(s)
Baumgartner  J. D., Glauser  M. P.
ISSN
0002-9343
Publication state
Published
Issued date
10/1984
Peer-reviewed
Oui
Volume
77
Number
4C
Pages
54-8
Notes
Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial --- Old month value: Oct 19
Abstract
The safety of ceftriaxone was compared with that of amoxicillin in a randomized study of 91 patients with community-acquired pneumonia. The origin of infection was similar in the two groups. It was proven or probable Streptococcus pneumoniae in 50 percent of the patients and remained uncertain in 40 percent. Ninety percent of the patients who received ceftriaxone were clinically cured compared with 69 percent of those given amoxicillin (p less than 0.05). However, this difference was not apparent among the patients with proven or probable pneumococcal pneumonia. No severe clinical side effects were observed. Cutaneous reactions were more prevalent in the amoxicillin group, whereas mild diarrhea and mucosal candidiasis were more frequent in the ceftriaxone group. Reversible neutropenia was observed in two patients treated with ceftriaxone and none of those treated with amoxicillin.
Keywords
Adult Aged Amoxicillin/*adverse effects Cefotaxime/adverse effects/*analogs & derivatives Ceftriaxone Female Humans Male Middle Aged Neutropenia/chemically induced Penicillins/adverse effects Pneumococcal Infections/drug therapy Pneumonia/*drug therapy/etiology
Pubmed
Web of science
Create date
19/01/2008 18:12
Last modification date
20/08/2019 13:19
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