High versus low dose irradiation for tumor immune reprogramming.

Détails

ID Serval
serval:BIB_330632946BBD
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
High versus low dose irradiation for tumor immune reprogramming.
Périodique
Current opinion in biotechnology
Auteur(s)
de Olza M.O., Bourhis J., Irving M., Coukos G., Herrera F.G.
ISSN
1879-0429 (Electronic)
ISSN-L
0958-1669
Statut éditorial
Publié
Date de publication
10/2020
Peer-reviewed
Oui
Volume
65
Pages
268-283
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Local administration of ionizing radiation to tumors can promote anticancer immune responses that lead to the abscopal regression of distant metastases, especially in patients receiving systemic immune-checkpoint inhibitors. Growing preclinical evidence indicates that high-dose irradiation administered locally to destroy malignant lesions, can promote the release of danger-associated molecular patterns that lead to the recruitment of immune cells, thus inducing a systemic response against tumor antigens that protects against local disease relapse and also mediates distant antineoplastic effects. An accumulating body of preclinical evidence supports also the implementation of low-dose irradiation to induce tumor immune reprogramming. Here, we provide the rationale for a clinical research agenda to refine future clinical practice based on innovative combinations of radiation-immunotherapy.
Pubmed
Web of science
Création de la notice
14/09/2020 12:33
Dernière modification de la notice
06/01/2021 6:24
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