High versus low dose irradiation for tumor immune reprogramming.

Details

Serval ID
serval:BIB_330632946BBD
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
High versus low dose irradiation for tumor immune reprogramming.
Journal
Current opinion in biotechnology
Author(s)
de Olza M.O., Bourhis J., Irving M., Coukos G., Herrera F.G.
ISSN
1879-0429 (Electronic)
ISSN-L
0958-1669
Publication state
Published
Issued date
01/09/2020
Peer-reviewed
Oui
Volume
65
Pages
268-283
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: aheadofprint
Abstract
Local administration of ionizing radiation to tumors can promote anticancer immune responses that lead to the abscopal regression of distant metastases, especially in patients receiving systemic immune-checkpoint inhibitors. Growing preclinical evidence indicates that high-dose irradiation administered locally to destroy malignant lesions, can promote the release of danger-associated molecular patterns that lead to the recruitment of immune cells, thus inducing a systemic response against tumor antigens that protects against local disease relapse and also mediates distant antineoplastic effects. An accumulating body of preclinical evidence supports also the implementation of low-dose irradiation to induce tumor immune reprogramming. Here, we provide the rationale for a clinical research agenda to refine future clinical practice based on innovative combinations of radiation-immunotherapy.
Pubmed
Create date
14/09/2020 12:33
Last modification date
02/10/2020 5:26
Usage data