The INHANCE consortium: toward a better understanding of the causes and mechanisms of head and neck cancer.

Détails

ID Serval
serval:BIB_32815B096C07
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The INHANCE consortium: toward a better understanding of the causes and mechanisms of head and neck cancer.
Périodique
Oral diseases
Auteur(s)
Winn D.M., Lee Y.C., Hashibe M., Boffetta P.
Collaborateur(s)
INHANCE consortium
Contributeur(s)
Agudo A., Ahrens W., Bencko V., Benhamou S., Boccia S., Bosetti C., Brennan P., Brenner H., Cadoni G., Castellsague X., Chen C., Conway D., Curado M.P., D'Souza G., Maso L.D., Daudt A.W., De Ruyck K., Diergaarde B., Eluf- Neto J., Fabianova E., Fernandez L., Franceschi S., Gillison M., Haddad R.I., Hayes R., Healy C., Herrero R., Hofmann J., Holcátová I., Hung R., Kelsey K., Kjaerheim K., Koifman S., La Vecchia C., Lacko M., Lagiou P., Lazarus P., Levi F., Li G., Lissowska J., Liu G., Luce D., Macfarlane T., Mahimkar M., Mates D., Matsuo K., McClean M., Menezes A., Menvielle G., Merletti F., Moysich K., Muscat J., Olshan A., Pawlita M., Peters W.H., Ramroth H., Rozek L., Rudnai P., Schantz S., Schwartz S., Serraino D., Shangina O., Simonato L., Smith E., Stucker I., Sturgis E.M., Szeszenia-Dabrowska N., Thomson P., Vaughan T., Vilensky M., Wolf G., unsch-Filho V.W., Yu G., Zaridze D., Zatonski W., Zevallos J.P., Zhang Z.F., Zheng T.Z., Znaor A.
ISSN
1601-0825 (Electronic)
ISSN-L
1354-523X
Statut éditorial
Publié
Date de publication
09/2015
Volume
21
Numéro
6
Pages
685-693
Langue
anglais
Notes
Publication types: Journal Article ; Review

Résumé
The International Head and Neck Cancer Epidemiology (INHANCE) consortium is a collaboration of research groups leading large epidemiology studies to improve the understanding of the causes and mechanisms of head and neck cancer. The consortium includes investigators of 35 studies who have pooled their data on 25 500 patients with head and neck cancer (i.e., cancers of the oral cavity, oropharynx, hypopharynx, and larynx) and 37 100 controls. The INHANCE analyses have confirmed that tobacco use and alcohol intake are key risk factors of these diseases and have provided precise estimates of risk and dose response, the benefit of quitting, and the hazard of smoking even a few cigarettes per day. Other risk factors include short height, lean body mass, low education and income, and a family history of head and neck cancer. Risk factors are generally similar for oral cavity, pharynx, and larynx, although the magnitude of risk may vary. Some major strengths of pooling data across studies include more precise estimates of risk and the ability to control for potentially confounding factors and to examine factors that may interact with each other. The INHANCE consortium provides evidence of the scientific productivity and discoveries that can be obtained from data pooling projects.

Mots-clé
Alcohol Drinking/adverse effects, Cooperative Behavior, Diet, Head and Neck Neoplasms/epidemiology, Head and Neck Neoplasms/etiology, Head and Neck Neoplasms/genetics, Humans, Risk Factors, Smoking/adverse effects, Socioeconomic Factors
Pubmed
Création de la notice
04/05/2017 10:04
Dernière modification de la notice
20/08/2019 13:18
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