The INHANCE consortium: toward a better understanding of the causes and mechanisms of head and neck cancer.

Details

Serval ID
serval:BIB_32815B096C07
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The INHANCE consortium: toward a better understanding of the causes and mechanisms of head and neck cancer.
Journal
Oral diseases
Author(s)
Winn D.M., Lee Y.C., Hashibe M., Boffetta P.
Working group(s)
INHANCE consortium
Contributor(s)
Agudo A., Ahrens W., Bencko V., Benhamou S., Boccia S., Bosetti C., Brennan P., Brenner H., Cadoni G., Castellsague X., Chen C., Conway D., Curado M.P., D'Souza G., Maso L.D., Daudt A.W., De Ruyck K., Diergaarde B., Eluf- Neto J., Fabianova E., Fernandez L., Franceschi S., Gillison M., Haddad R.I., Hayes R., Healy C., Herrero R., Hofmann J., Holcátová I., Hung R., Kelsey K., Kjaerheim K., Koifman S., La Vecchia C., Lacko M., Lagiou P., Lazarus P., Levi F., Li G., Lissowska J., Liu G., Luce D., Macfarlane T., Mahimkar M., Mates D., Matsuo K., McClean M., Menezes A., Menvielle G., Merletti F., Moysich K., Muscat J., Olshan A., Pawlita M., Peters W.H., Ramroth H., Rozek L., Rudnai P., Schantz S., Schwartz S., Serraino D., Shangina O., Simonato L., Smith E., Stucker I., Sturgis E.M., Szeszenia-Dabrowska N., Thomson P., Vaughan T., Vilensky M., Wolf G., unsch-Filho V.W., Yu G., Zaridze D., Zatonski W., Zevallos J.P., Zhang Z.F., Zheng T.Z., Znaor A.
ISSN
1601-0825 (Electronic)
ISSN-L
1354-523X
Publication state
Published
Issued date
09/2015
Volume
21
Number
6
Pages
685-693
Language
english
Notes
Publication types: Journal Article ; Review

Abstract
The International Head and Neck Cancer Epidemiology (INHANCE) consortium is a collaboration of research groups leading large epidemiology studies to improve the understanding of the causes and mechanisms of head and neck cancer. The consortium includes investigators of 35 studies who have pooled their data on 25 500 patients with head and neck cancer (i.e., cancers of the oral cavity, oropharynx, hypopharynx, and larynx) and 37 100 controls. The INHANCE analyses have confirmed that tobacco use and alcohol intake are key risk factors of these diseases and have provided precise estimates of risk and dose response, the benefit of quitting, and the hazard of smoking even a few cigarettes per day. Other risk factors include short height, lean body mass, low education and income, and a family history of head and neck cancer. Risk factors are generally similar for oral cavity, pharynx, and larynx, although the magnitude of risk may vary. Some major strengths of pooling data across studies include more precise estimates of risk and the ability to control for potentially confounding factors and to examine factors that may interact with each other. The INHANCE consortium provides evidence of the scientific productivity and discoveries that can be obtained from data pooling projects.

Keywords
Alcohol Drinking/adverse effects, Cooperative Behavior, Diet, Head and Neck Neoplasms/epidemiology, Head and Neck Neoplasms/etiology, Head and Neck Neoplasms/genetics, Humans, Risk Factors, Smoking/adverse effects, Socioeconomic Factors
Pubmed
Create date
04/05/2017 10:04
Last modification date
20/08/2019 13:18
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