Boosting mitochondrial health to counteract neurodegeneration.

Détails

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Etat: Public
Version: de l'auteur⸱e
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_3223F1F38608
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Boosting mitochondrial health to counteract neurodegeneration.
Périodique
Progress in neurobiology
Auteur⸱e⸱s
Burtscher J., Romani M., Bernardo G., Popa T., Ziviani E., Hummel F.C., Sorrentino V., Millet G.P.
ISSN
1873-5118 (Electronic)
ISSN-L
0301-0082
Statut éditorial
Publié
Date de publication
08/2022
Peer-reviewed
Oui
Volume
215
Pages
102289
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Mitochondrial health is based on a delicate balance of specific mitochondrial functions (e.g. metabolism, signaling, dynamics) that are impaired in neurodegenerative diseases. Rescuing mitochondrial function by selectively targeting mitochondrial stressors, such as reactive oxygen species, inflammation or proteotoxic insults ("bottom-up" approaches) thus is a widely investigated therapeutic strategy. While successful in preclinical studies, these approaches have largely failed to show clear clinical benefits. Promoting the capacity of mitochondria - and other cellular components - to restore a healthy cellular environment is a promising complementary or alternative approach. Herein, we provide a non-technical overview for neurologists and scientists interested in brain metabolism on neuroprotective strategies targeting mitochondria and focus on top-down interventions such as metabolic modulators, exercise, dietary restriction, brain stimulation and conditioning. We highlight general conceptual differences to bottom-up approaches and provide hypotheses on how these mechanistically comparatively poorly characterized top-down therapies may work, discussing notably mitochondrial stress responses and mitohormesis.
Mots-clé
Exercise/physiology, Humans, Mitochondria/metabolism, Neurodegenerative Diseases/metabolism, Neurodegenerative Diseases/therapy, Neuroprotection, Reactive Oxygen Species/metabolism, Ageing, Conditioning, Exercise, Hormesis, Mitochondria, Neurodegeneration
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/05/2022 19:24
Dernière modification de la notice
20/07/2022 5:37
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