Boosting mitochondrial health to counteract neurodegeneration.
Details
Request a copy Under indefinite embargo.
UNIL restricted access
State: Public
Version: author
License: CC BY-NC-ND 4.0
UNIL restricted access
State: Public
Version: author
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_3223F1F38608
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Boosting mitochondrial health to counteract neurodegeneration.
Journal
Progress in neurobiology
ISSN
1873-5118 (Electronic)
ISSN-L
0301-0082
Publication state
Published
Issued date
08/2022
Peer-reviewed
Oui
Volume
215
Pages
102289
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Mitochondrial health is based on a delicate balance of specific mitochondrial functions (e.g. metabolism, signaling, dynamics) that are impaired in neurodegenerative diseases. Rescuing mitochondrial function by selectively targeting mitochondrial stressors, such as reactive oxygen species, inflammation or proteotoxic insults ("bottom-up" approaches) thus is a widely investigated therapeutic strategy. While successful in preclinical studies, these approaches have largely failed to show clear clinical benefits. Promoting the capacity of mitochondria - and other cellular components - to restore a healthy cellular environment is a promising complementary or alternative approach. Herein, we provide a non-technical overview for neurologists and scientists interested in brain metabolism on neuroprotective strategies targeting mitochondria and focus on top-down interventions such as metabolic modulators, exercise, dietary restriction, brain stimulation and conditioning. We highlight general conceptual differences to bottom-up approaches and provide hypotheses on how these mechanistically comparatively poorly characterized top-down therapies may work, discussing notably mitochondrial stress responses and mitohormesis.
Keywords
Exercise/physiology, Humans, Mitochondria/metabolism, Neurodegenerative Diseases/metabolism, Neurodegenerative Diseases/therapy, Neuroprotection, Reactive Oxygen Species/metabolism, Ageing, Conditioning, Exercise, Hormesis, Mitochondria, Neurodegeneration
Pubmed
Web of science
Open Access
Yes
Create date
26/05/2022 20:24
Last modification date
20/07/2022 6:37