Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19.
Détails
Télécharger: 37020259_BIB_31798B2B6490.pdf (2590.44 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_31798B2B6490
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19.
Périodique
Genome medicine
Collaborateur⸱rice⸱s
COVID Human Genetic Effort, COVIDeF Study Group, French COVID Cohort Study Group, CoV-Contact Cohort, COVID-STORM Clinicians, COVID Clinicians, Orchestra Working Group, Amsterdam UMC Covid-19 Biobank, NIAID-USUHS COVID Study Group
Contributeur⸱rice⸱s
Abel L., Al-Muhsen S., Al-Mulla F., Anderson M.S., Andreakos E., Arias A.A., Feldman H.B., Belot A., Biggs C.M., Bogunovic D., Bondarenko A., Bousfiha A.A., Brodin P., Bryceson Y., Bustamante C.D., Chakravorty S., Christodoulou J., Desai M., Drolet B.A., Baghdadi J.E., Espinosa-Padilla S., Franco J.L., Froidure A., Hagin D., Henrickson S.E., Hsieh EWY, Husebye E., Imai K., Itan Y., Jarvis E.D., Karamitros T., Kisand K., Ku C.L., Ling Y., Lucas C.L., Maródi L., Meyts I., Milner J.D., Mironska K., Morio T., Ng LFP, Notarangelo L.D., O'Farrelly C., Okada S., Planas A.M., Quintana-Murci L., Renia L., Resnick I., Rodríguez-Gallego C., Sancho-Shimizu V., Sediva A., Seppänen MRJ, Shcherbina A., Slaby O., Snow A.L., Soler-Palacín P., Spaan A.N., Tancevski I., Tangye S.G., Ramaswamy S., Turvey S.E., Uddin F., Uddin M.J., van de Beek D., Vinh D.C., Zatz M., Su H.C., Casanova J.L., Bureau S., Vacher Y., Gysembergh-Houal A., Demerville L., Chachoua A., Abad S., Abassi R., Abdellaoui A., Abdelmalek A., Abdoul H., Abergel H., Abeud F., Abgrall S., Abisror N., Adechian M., Aderdour N., Admane H.F., Adnet F., Afritt S., Agostini H., Aguilar C., Agut S., Aiello T.F., Kaci M.A., Oufella H.A., Ajeenthiravasan G., Alauzy V., Alby-Laurent F., Allard L., Alyanakian M.A., Borrero B.A., Amam S., Amrouche L., Andronikof M., Anglicheau D., Anguel N., Annane D., Aounzou M., Aparicio C., Aratus G., Arlet J.B., Arzoine J., Aslangul E., Assefi M., Aubry A., Audiffred L., Audureau E., Auger C.N., Auregan J.C., Awotar C., Milla S.A., Azan D., Azemar L., Azzouguen B., Elrufaai M.B., Badsi A., Bakouboula P., Balcerowiak C., Balde F., Baldivia E., Bangamingo E.F., Baptiste A., Baran-Marszak F., Barau C., Barget N., Baronnet F., Barthelemy R., Baudel J.L., Baudry C., Baudry E., Beaugerie L., Belamri A., Belaube N., Belilita R., Bellassen P., Belmokhtar R., Beltran I., Benainous R., Benallaoua M., Benamouzig R., Benbara A., Benhida J., Benkhelouf A., Benlagha J., Benmostafa C., Benothmane S., Bentifraouine M., Berard L., Bernier Q., Berti E., Bertier A., Berton L., Bessis S., Beurton A., Bianco C., Bianquis C., Bidar F., Blanche P., Blayau C., Bleibtreu A., Blin E., Bloch-Queyrat C., Boissier M.C., Bollens D., Bolzoni M., Bompard R.P., Bonnet N., Bonnouvrier J., Botha S., Boucenna W., Bouchama F., Bouchaud O., Bouchghoul H., Boudjebla T., Boudjema N., Bouffard C., Bougle A., Bouguerra M., Bouras L., Bourcier A., Durand A.B., Bourrier A., Bouscarat F., Bouvry D., Bouziri N., Bouzrara O., Bribier S., Brugier D., Brunel M., Bui E., Buisson A., Bukreyeva I., Bureau C., Cadranel J., Cailhol J., Calin R., Vega C.C., Canavaggio P., Cancella M., Cantin D., Cao A., Carbillon L., Carlier N., Cassard C., Castor G., Cauchy M., Cha O., Chaigne B., Challal S., Champion K., Chariot P., Chas J., Chauveau S., Chauvin A., Chauvin C., Chavarot N., Chebbout K., Cherai M., Cherubini I., Chevalier A., Chiarabini T., Chinet T., Chocron R., Choinier P., Chommeloux J., Choquet C., Choupeaux L., Chousterman B., Ciocan D., Clarke A., Clavere G., Clavier F., Clement K., Clerc S., Cohen Y., Cohen F., Cohen A., Coilly A., Colboc H., Colin P., Collet M., Comarmond C., Combacon E., Combes A., Comparon C., Constantin J.M., Cordel H., Cordier A.G., Costantini A., Chalumeau N.C., Couffignal C., Coupeau D., Creange A., Lamarre Y.C., Da Silveira C., Kayani SDGE, De Castro N., De Rycke Y., Del Pozo L., Delannoy Q., Delay M., Deleris R., Delforge J., Delphine L., Demare N., Demeret S., Demoule A., Deniau A., Depret F., Derolez S., Derradji O., Derridj N., Descamps V., Deschamps L., Desconclois C., Desnos C., Desongins K., Dhote R., Diallo B., Didier M., Diemer M., Diez S., Djadi-Prat J., Monnory F.D., Djebara S., Djebra N., Djietcheu M., Djillali H., Djouadi N., Donneger S., Dos Santos C., Dournon N., Dres M., Droctove L., Drogrey M., Dropy M., Drouet E., Dubosq V., Dubreucq E., Dubus E., Duchemann B., Duchenoy T., Dudoignon E., Dufau R., Dumas F., Duran C., Duron E., Durrbach A., Duvivier C., Ebstein N., Khalifa J.E., Elabbadi A., Elie C., Ernotte G., Esling A., Etienne M., Eyer X., Fartoukh M.S., Fayali T., Fermaut M., Fiorentino A., Fliss S., Fournier M.C., Fournier B., Francois H., Freynet O., Frigout Y., Fromont I., Fuentes A., Furet T., Galand J., Garnier M., Gaubert A., Gaudry S., Gaugain S., Gauthier D., Gautier M., Georgin-Lavialle S., Geromin D., Ghalayini M., Ghaleh B., Ghezal M., Gibelin A., Gimeno L., Girard B., Leprieur B.G., Gomes D., Gomes-Pires E., Gouge A., Gouja A., Goulet H., Goupil S., De Bouille J.G., Gras J., Greffe S., Grimaldi L., Guedeney P., Guidet B., Guillo M., Gulczynski M., Hadjam T., Haguenauer D., Hammal S., Hammoudi N., Hanon O., Harrois A., Hautem C., Hekimian G., Heming N., Hermine O., Ho S., Houllier M., Huot B., Huscenot T., Saied W., Ikherbane G., Imarazene M., Ingiliz P., Iratni L., Jaureguiberry S., Jean-Marc J.F., Jeyarajasingham D., Jouany P., Jouis V., Jourdaine C., Kafif O., Kallala R., Katsahian S., Kelesyan L., Keo V., Ketz F., Khamis W., Khelili E., Khellaf M., Youkou CGK, Kounis I., Kpalma G., Krause J., Labbe V., Lacombe K., Lacorte J.M., Lafont A.G., Lafont E., Lagha L., Lamhaut L., Lancelot A., Landman C., Lanternier F., Larcheveque C., Combe C.L., Lassel L., Laverdant B., Lavergne C., Lavillegrand J.R., Lazureanu P., Le Guennec L., Leberre L., Leblanc C., Leboyer M., Lecomte F., Lecorre M., Leenhardt R., Lefebvre M., Lefebvre B., Legendre P., Leger A., Legros L., Legrosse J., Lehuunghia S., Lemarec J., Leporrier-Ext J., Lesein M., Lesur H., Levy V., Levy A., Lopes E., Lopes A., Lopez V., Lopinto J., Lortholary O., Louadah B., Loze B., Lucas M.L., Lucasamichi A., Luong L.B., Magazimama-Ext A., Maingret D., Mameri L., Manivet P., Mansouri C., Marcault E., Marey J., Marin N., Marois C., Martin O., Martineau L., Martinez-Lopez C., Martyniuck P., De Farcy P.M., Marzouk N., Masmoudi R., Mebazaa A., Mechai F., Mecozzi F., Mediouni C., Megarbane B., Meghadecha M., Mejean É., Mekinian A., Abdelhadi N.M., Mekni R., Meliti T.S., Lima B.M., Meng P., Merbah S., Messani F., Messaoudi Y., Mewasing B.I., Meziane L., Michelot-Burger C., Mignot F., Minka F.H., Miyara M., Moine P., Molina J.M., Montegnies-Boulet A., Monti A., Montlahuc C., Montout A.L., Moores A., Morbieu C., Mortelette H., Mouly S., Muzaffar R., Nacerddine C.I., Nadal M., Nadif H., Nassarmadji K., Natella P., Ndingamondze S., Neraal S., Nguyen C., N'Guyen B., Larmurier I.N., Nlomenyengue L., Noel N., Nunes H., Omar E., Ouazene Z., Ouedraogo E., Ouelaa W., Oukhedouma A., Amara Y.O., Oya H., Oziel J., Padilla T., Paillaud E., Paiva S., Parfait B., Parize P., Parizot C., Parrot A., Pavot A., Peaudecerf L., Pene F., Pepin M., Pernet J., Pernin C., Petit M., Peyrony O., Pietri M.P., Pietri O., De Chambrun M.P., Pinson M., Pintado C., Piquard V., Pires C., Planquette B., Poirier S., Pomel A.L., Pons S., Ponscarme D., Pourcelot A., Pourcher V., Pouvaret A., Prever F., Previlon M., Prevost M., Provoost M.J., Quemeneur C., Rafat C., Rami A., Ranque B., Raphael M., Raphalen J.H., Rastoin A., Raux M., Rebai A., Reby M., Regent A., Regrag A., Resche-Rigon M., Ressaire Q., Richard C., Richard M., Robert M., Rohaut B., Rolland-Debord C., Ropers J., Roque-Afonso A.M., Rosso C., Rousseaux M., Rousseaux N., Roux S., Roux L., Rouzaud C., Rozes A., Rubenstein E., Sabate J.M., Sabet S., Sacleux S.C., Kermanach N.S., Saliba F., Salmon D., Savale L., Savary G., Sberro R., Scemla A., Schlemmer F., Schwartz M., Sedfi S., Sefir-Kribel S., Seksik P., Sellier P., Selves A., Sembach N., Semerano L., Senat M.V., Sene D., Serris A., Sese L., Sghiouar N., Sigaux J., Siguier M., Silvain J., Simon N., Simon T., Skandri L.I., Slimani M., Snauwaert A., Sokol H., Soliman H., Soltani N., Soyer B., Steg G., Suarez L., Szwebel T.A., Taffame K., Tantet C., Tateo M., Theodose I., Thiebaud P.C., Thomas C., Tiercelet K., Tisserand J., Tomczak C., Torelino K., Touam-Ext F., Toumi L., Toury G., Toy-Miou M., Lien OTDT, Trandinh A., Treluyer J.M., Trinque B., Truchot J., Tunesi S., Turpin M., Turpin A., Urbina T., Narvaez R.U., Uzunhan Y., Vaittinadaayar P., Valent A., Valentian M., Valin N., Vallet H., Vaz M., Vazquezibarra M.A., Vedie B., Velly L., Verstuyft C., Viallette C., Vicaut E., Vignes D., Vimpere D., Virlouvet M., Voiriot G., Voisot L., Weiss E., Weiss N., Winchenne A., Yordanov Y., Zafrani L., Zaidan M., Zaidi W., Zak C., Zarhrate-Ghoul A., Zatout O., Zeino S., Zeitouni M., Zemirli N., Zerah L., Zia O., Ziol M., Zolario O., Zuber J., Abel L., Andrejak C., Angoulvant F., Bachelet D., Bartoli M., Basmaci R., Behilill S., Beluze M., Benkerrou D., Bhavsar K., Bouadma L., Bouchez S., Bouscambert M., Cervantes-Gonzalez M., Chair A., Chirouze C., Coelho A., Couffignal C., Couffin-Cadiergues S., d'Ortenzio E., Debray M.P., Deconinck L., Deplanque D., Descamps D., Desvallée M., Diallo A., Diouf A., Dorival C., Dubos F., Duval X., Elharrar B., Eloy P., Enouf V., Esperou H., Esposito-Farese M., Etienne M., Devouge E.F., Gault N., Gaymard A., Ghosn J., Gigante T., Gilg M., Guedj J., Hoctin A., Hoffmann I., Houas I., Hulot J.S., Jaafoura S., Kafif O., Kaguelidou F., Kali S., Khalil A., Khan C., Laouénan C., Laribi S., Le M., Le Hingrat Q., Le Mestre S., Le Nagard H., Lescure F.X., Letrou S., Levy Y., Lina B., Lingas G., Lucet J.C., Malvy D., Mambert M., Mentré F., Meziane A., Mouquet H., Mullaert J., Neant N., Nguyen D., Noret M., Nseir S., Papadopoulos A., Paul C., Peiffer-Smadja N., Perpoint T., Petrov-Sanchez V., Peytavin G., Pham H., Picone O., Piquard V., Puéchal O., Rabaud C., Rosa-Calatrava M., Rossignol B., Rossignol P., Roy C., Schneider M., Su R., Tardivon C., Tellier M.C., Téoulé F., Terrier O., Timsit J.F., Tual C., Van Der Werf S., Vanel N., Veislinger A., Visseaux B., Wiedemann A., Yazdanpanah Y., Alavoine L., Behillil S., Burdet C., Charpentier C., Dechanet A., Descamps D., Duval X., Ecobichon J.L., Enouf V., Frezouls W., Houhou N., Kafif O., Lehacaut J., Letrou S., Lina B., Lucet J.C., Manchon P., Nouroudine M., Piquard V., Quintin C., Thy M., van der Werf S., Vignali V., Visseaux B., Yazdanpanah Y., Chahine A., Waucquier N., Migaud M.C., Deplanque D., Djossou F., Mergeay-Fabre M., Lucarelli A., Demar M., Bruneau L., Gérardin P., Maillot A., Payet C., Laviolle B., Laine F., Paris C., Desille-Dugast M., Fouchard J., Malvy D., Nguyen D., Pistone T., Perreau P., Gissot V., Goas CLE, Montagne S., Richard L., Chirouze C., Bouiller K., Desmarets M., Meunier A., Bourgeon M., Lefévre B., Jeulin H., Legrand K., Lomazzi S., Tardy B., Gagneux-Brunon A., Bertholon F., Botelho-Nevers E., Christelle K., Nicolas L., Roufai L., Amat K., Couffin-Cadiergues S., Espérou H., Hendou S., Foti G., Bellani G., Citerio G., Contro E., Pesci A., Valsecchi M.G., Cazzaniga M., Abad J., Accordino G., Achille C., Aguilera-Albesa S., Aguiló-Cucurull A., Özkan E.A., Albisures JAR, Aldave J.C., Ramos M.A., Khan T.A., Aliberti A., Nadji S.A., Alkan G., AlKhater S.A., Allardet-Servent J., Alshahrani M.S., Alsina L., Alyanakian M.A., Borrero B.A., Amoura Z., Antolí A., Arrestier R., Aubart M., Auguet T., Avramenko I., Aytekin G., Azot A., Bahram S., Bajolle F., Baldanti F., Baldolli A., Ballester M., Feldman H.B., Barrou B., Basso S., Bayhan G.I., Belot A., Bezrodnik L., Bilbao A., Blanchard-Rohner G., Blanco I., Blandinières A., Blázquez-Gamero D., Bleibtreu A., Bloomfield M., Bolivar-Prados M., Bondarenko A., Borghesi A., Borie R., Botdhlo-Nevers E., Bousfiha A.A., Bousquet A., Boutolleau D., Bouvattier C., Boyarchuk O., Bravais J., Briones M.L., Brunner M.E., Bruno R., Bueno MRP, Bukhari H., Bustamante J., Agra JJC, Capra R., Carapito R., Carrabba M., Casasnovas C., Caseris M., Cassaniti I., Castelle M., Castelli F., de Vera M.C., Castro M.V., Catherinot E., Celik J.B., Ceschi A., Chalumeau M., Charbit B., Cheng M.P., Clavé P., Clotet B., Codina A., Cohen Y., Comarmond C., Combes A., Comoli P., Corsico A.G., Sozeri B., Coşkuner T., Cvetkovski A., Cyrus C., Dalmau D., Danion F., Darley D.R., Das V., Dauby N., Dauger S., De Munter P., de Pontual L., Dehban A., Delplancq G., Demoule A., Desguerre I., Di Sabatino A., Diehl J.L., Dobbelaere S., Domínguez-Garrido E., Dubost C., Ekwall O., Bozdemir Ş.E., Elnagdy M.H., Emiroglu M., Endo A., Erdeniz E.H., Aytekin S.E., Lasa MPE, Euvrard R., Fabio G., Faivre L., Falck A., Fartoukh M., Faure M., Arquero M.F., Ferrer R., Ferreres J., Francois B., Fumadó V., Fung KSC, Fusco F., Gagro A., Solis B.G., Garçon P., Gaussem P., Gayretli Z., Gil-Herrera J., Gilardin L., Gatineau A.G., Girona-Alarcón M., Godínez KAC, Goffard J.C., Gonzales N., Gonzalez-Granado L.I., González-Montelongo R., Guerder A., Gülhan B., Gumucio V.D., Hanitsch L.G., Gunst J., Hadjadj J., Hariyan T., Hatipoglu N., Heppekcan D., Hernandez-Brito E., Ho P.K., Holanda-Peña M.S., Horcajada J.P., Hraiech S., Humbert L., Hung IFN, Iglesias A.D., Íñigo-Campos A., Jamme M., Arranz M.J., Jimeno M.T., Jordan I., Kanik-Yüksek S., Kara Y.B., Karahan A., Yasar K.K., Kasapcopur O., Kashimada K., Demirkol Y.K., Kido Y., Kizil C., Kılıç A.O., Klocperk A., Koutsoukou A., Król Z.J., Ksouri H., Kuentz P., Kwan AMC, Kwan YWM, Kwok JSY, Lagier J.C., Lam DSY, Lampropoulou V., Lanternier F., Le Bourgeois F., Leo Y.S., Lopez R.L., Leung D., Levin M., Levy M., Lévy R., Li Z., Lilleri D., Lima EJAB, Linglart A., López-Collazo E., Lorenzo-Salazar J.M., Louapre C., Lubetzki C., Lung K.C., Luyt C.E., Lye D.C., Magnone C., Marchioni E., Marioli C., Marjani M., Marques L., Pereira J.M., Martín-Nalda A., Pueyo D.M., Marzana I., Mata-Martínez C., Mathian A., Matos LRB, Matthews G.V., Mayaux J., McLaughlin-Garcia R., Meersseman P., Mège J.L., Mekontso-Dessap A., Melki I., Meloni F., Meritet J.F., Merlani P., Akcan Ö.M., Meyts I., Mezidi M., Millereux M., Million M., Mirault T., Mircher C., Mirsaeidi M., Mizoguchi Y., Modi B.P., Mojoli F., Moncomble E., Melián A.M., Martinez A.M., Morandeira F., Mordacq C., Mouly S.J., Muñoz-Barrera A., Nafati C., Nagashima S., Nakagama Y., Neven B., Neves J.F., Ng LFP, Ng Y.Y., Nielly H., Medina Y.N., Cuadros E.N., Ocejo-Vinyals J.G., Okamoto K., Oualha M., Ouedrani A., Özçelik T., Ozkaya-Parlakay A., Pagani M., Papadaki M., Parizot C., Parola P., Pascreau T., Paul S., Paz-Artal E., Pedraza S., Pellecer NCG, Pellegrini S., Pérez-Fernández X.L., Philippe A., Philippot Q., Picod A., de Chambrun M.P., Piralla A., Ploin D., Poissy J., Poncelet G., Poulakou G., Pouletty M.S., Pourshahnazari P., Qiu-Chen J.L., Quentric P., Rambaud T., Raoult D., Raoult V., Rebillat A.S., Redin C., Resmini L., Ricart P., Richard J.C., Rigo-Bonnin R., Rivet N., Rocamora-Blanch G., Rodero M.P., Rodrigo C., Rodriguez L.A., Rodriguez-Palmero A., Romero C.S., Rothenbuhler A., Roux D., Rovina N., Rozenberg F., Ruch Y., Ruiz M., Del Prado MYR, Ruiz-Rodriguez J.C., Sabater-Riera J., Saks K., Salagianni M., Sanchez O., Sánchez-Montalvá A., Sánchez-Ramón S., Schidlowski L., Schluter A., Schmidt J., Schmidt M., Schuetz C., Schweitzer C.E., Scolari F., Sediva A., Seijo L., Seminario A.G., Sene D., Seng P., Senoglu S., Seppänen M., Llovich A.S., Shcherbina A., Siguret V., Siouti E., Smadja D.M., Smith N., Solanich X., Solé-Violán J., Soler C., Soler-Palacín P., Sözeri B., Stella G.M., Stepanovskiy Y., Stoclin A., Taccone F., Taupin J.L., Tavernier S.J., Tello L.V., Terrier B., Thiery G., Thorball C., Thorn K., Thumerelle C., Tolstrup M., Tomasoni G., Toubiana J., Alvarez J.T., Triantafyllia V., Trouillet-Assant S., Troya J., Tsang OTY, Tserel L., Tso EYK, Tucci A., Öz ŞKT, Ursini M.V., Utsumi T., Uzunhan Y., Vabres P., Valencia-Ramos J., Van Den Rym A.M., Vandernoot I., Velez-Santamaria V., Veliz SPZ, Vidigal M.C., Viel S., Villain C., Vilaire-Meunier M.E., Villar-García J., Vincent A., Voiriot G., Volokha A., Vuotto F., Wauters E., Wauters J., Wu AKL, Wu T.C., Yahşi A., Yesilbas O., Yildiz M., Young B.E., Yükselmiş U., Zatz M., Zecca M., Zuccaro V., Van Praet J., Lambrecht B.N., Van Braeckel E., Bosteels C., Hoste L., Hoste E., Bauters F., De Clercq J., Heijmans C., Slabbynck H., Naesens L., Florkin B., Boulanger C., Vanderlinden D., Abel L., Berkell M., Carelli V., Fiorentino A., Malhotra S., Mattiaccio A., Pippucci T., Seri M., Tacconelli E., van Agtmael M., Algera A.G., Appelman B., van Baarle F., Bax D., Beudel M., Bogaard H.J., Bomers M., Bonta P., Bos L., Botta M., de Brabander J., de Bree G., de Bruin S., Buis DTP, Bugiani M., Bulle E., Cloherty OCA, Dijkstra M., Dongelmans D.A., Dujardin RWG, Elbers P., Fleuren L., Geijtenbeek SGT, Girbes A., Goorhuis B., Grobusch M.P., Hafkamp F., Hagens L., Hamann J., Harris V., Hemke R., Heunks SMHL, Hollmann M., Horn J., Hovius J.W., de Jong M.D., Koning R., Lim EHT, van Mourik N., Nellen J., Nossent E.J., Paulus F., Peters E., Pina-Fuentes DAI, van der Poll T., Preckel B., Prins J.M., Raasveld J., Reijnders T., de Rotte MCFJ, Schinkel M., Schultz M.J., Schrauwen FAP, Schuurmans A., Schuurmans J., Sigaloff K., Slim M.A., Smeele P., Smit M., Stijnis C.S., Stilma W., Teunissen C., Thoral P., Tsonas A.M., Tuinman P.R., van der Valk M., Veelo D., Volleman C., de Vries H., Vught L.A., van Vugt M., Wouters D., Zwinderman A.H., Brouwer M.C., Wiersinga W.J., Vlaar APJ, van de Beek D., Tompkins M.F., Alba C., Snow A.L., Hupalo D.N., Rosenberger J., Sukumar G., Wilkerson M.D., Zhang X., Lack J., Oler A.J., Dobbs K., Danielson J.J., Biondi A., Bettini L.R., D'Angio' M., Beretta I., Imberti L., Sottini A., Quaresima V., Quiros-Roldan E., Rossi C.
ISSN
1756-994X (Electronic)
ISSN-L
1756-994X
Statut éditorial
Publié
Date de publication
05/04/2023
Peer-reviewed
Oui
Volume
15
Numéro
1
Pages
22
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Intramural
Publication Status: epublish
Publication Status: epublish
Résumé
We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in ~ 80% of cases.
We report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded.
No gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P = 1.1 × 10 <sup>-4</sup> ) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR = 3.70[95%CI 1.3-8.2], P = 2.1 × 10 <sup>-4</sup> ). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR = 19.65[95%CI 2.1-2635.4], P = 3.4 × 10 <sup>-3</sup> ), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR = 4.40[9%CI 2.3-8.4], P = 7.7 × 10 <sup>-8</sup> ). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD] = 43.3 [20.3] years) than the other patients (56.0 [17.3] years; P = 1.68 × 10 <sup>-5</sup> ).
Rare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old.
We report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded.
No gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P = 1.1 × 10 <sup>-4</sup> ) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR = 3.70[95%CI 1.3-8.2], P = 2.1 × 10 <sup>-4</sup> ). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR = 19.65[95%CI 2.1-2635.4], P = 3.4 × 10 <sup>-3</sup> ), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR = 4.40[9%CI 2.3-8.4], P = 7.7 × 10 <sup>-8</sup> ). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD] = 43.3 [20.3] years) than the other patients (56.0 [17.3] years; P = 1.68 × 10 <sup>-5</sup> ).
Rare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old.
Mots-clé
Humans, Young Adult, Adult, Middle Aged, COVID-19, SARS-CoV-2, Toll-Like Receptor 3/genetics, Toll-Like Receptor 7, Interferon Type I, Autoantibodies, Immunity, Rare variants, Type I interferon
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/04/2023 16:05
Dernière modification de la notice
08/08/2024 6:31