Clinical proteomics: study of a cryogel

Détails

ID Serval
serval:BIB_3016A376D1A8
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Clinical proteomics: study of a cryogel
Périodique
Proteomics
Auteur(s)
Robert  D., Barelli  S., Crettaz  D., Bart  P. A., Schifferli  J. A., Betticher  D., Tissot  J. D.
ISSN
1615-9853 (Print)
Statut éditorial
Publié
Date de publication
07/2006
Volume
6
Numéro
13
Pages
3958-60
Notes
Journal Article --- Old month value: Jul
Résumé
Cryoproteins are proteins precipitating at low temperature. Usually, the precipitate contains immunoglobulins (Igs), and are therefore called cryoglobulins. Very rarely, Igs do not precipitate, but, upon cooling, form a gel. Here, we report a case of cryogel observed in a patient presenting with Waldenstrom's disease. Using proteomic tools, a monoclonal IgM was identified as being the cause of the gel formation. Furthermore, addition of H(2)O before incubation at 4 degrees C demonstrated that the monoclonal IgM was precipitable as a type I cryoglobulin (hypocryoglobulin).
Mots-clé
Adult Cryoglobulins/analysis Electrophoresis, Gel, Two-Dimensional *Gels Humans Immunoglobulin M/analysis *Proteomics Waldenstrom Macroglobulinemia/diagnosis/*immunology
Pubmed
Web of science
Création de la notice
25/01/2008 15:34
Dernière modification de la notice
20/08/2019 13:14
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