Clinical proteomics: study of a cryogel

Details

Serval ID
serval:BIB_3016A376D1A8
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Clinical proteomics: study of a cryogel
Journal
Proteomics
Author(s)
Robert  D., Barelli  S., Crettaz  D., Bart  P. A., Schifferli  J. A., Betticher  D., Tissot  J. D.
ISSN
1615-9853 (Print)
Publication state
Published
Issued date
07/2006
Volume
6
Number
13
Pages
3958-60
Notes
Journal Article --- Old month value: Jul
Abstract
Cryoproteins are proteins precipitating at low temperature. Usually, the precipitate contains immunoglobulins (Igs), and are therefore called cryoglobulins. Very rarely, Igs do not precipitate, but, upon cooling, form a gel. Here, we report a case of cryogel observed in a patient presenting with Waldenstrom's disease. Using proteomic tools, a monoclonal IgM was identified as being the cause of the gel formation. Furthermore, addition of H(2)O before incubation at 4 degrees C demonstrated that the monoclonal IgM was precipitable as a type I cryoglobulin (hypocryoglobulin).
Keywords
Adult Cryoglobulins/analysis Electrophoresis, Gel, Two-Dimensional *Gels Humans Immunoglobulin M/analysis *Proteomics Waldenstrom Macroglobulinemia/diagnosis/*immunology
Pubmed
Web of science
Create date
25/01/2008 16:34
Last modification date
20/08/2019 14:14
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