Arterial properties in relation to genetic variations in the adducin subunits in a white population.

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ID Serval
serval:BIB_2F27043D31DE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Arterial properties in relation to genetic variations in the adducin subunits in a white population.
Périodique
American Journal of Hypertension
Auteur⸱e⸱s
Seidlerová J., Staessen J.A., Bochud Murielle, Nawrot T., Casamassima N., Citterio L., Kuznetsova T., Jin Y., Manunta P., Richart T., Struijker-Boudier H.A., Fagard R., Filipovský J., Bianchi G.
ISSN
1879-1905[electronic]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
22
Numéro
1
Pages
21-26
Langue
anglais
Résumé
BACKGROUND: Adducin is a membrane skeleton protein, which consists of either alpha- and beta- or alpha- and gamma-subunits. We investigated whether arterial characteristics might be related to the genes encoding ADD1 (Gly460Trp-rs4961), ADD2 (C1797T-rs4984), and ADD3 (IVS11+386A>G-rs3731566). METHODS: We randomly recruited 1,126 Flemish subjects (mean age, 43.8 years; 50.3% women). Using a wall-tracking ultrasound system, we measured the properties of the carotid, femoral, and brachial arteries. We studied multivariate-adjusted phenotype-genotype associations, using a population- and family-based approach. RESULTS: In single-gene analyses, brachial diameter was 0.15 mm (P = 0.0022) larger, and brachial distensibility and cross-sectional compliance were 1.55 x 10(-3)/kPa (P = 0.013) and 0.017 mm(2)/kPa (P = 0.0029) lower in ADD3 AA than ADD3 GG homozygotes with an additive effect of the G allele. In multiple-gene analyses, the association of brachial diameter and distensibility with the ADD3 G allele occurred only in ADD1 GlyGly homozygotes. Otherwise, the associations between the arterial phenotypes in the three vascular beds and the ADD1 or ADD2 polymorphisms were not significant. In family-based analyses, the multivariate-adjusted heritability was 0.52, 0.38, and 0.30 for brachial diameter, distensibility, and cross-sectional compliance, respectively (P < 0.001). There was no evidence for population stratification (0.07 < or = P < or = 0.96). Transmission of the mutated ADD3 G allele was associated with smaller brachial diameter in 342 informative offspring (-0.12 +/- 0.04 mm; P = 0.0085) and in 209 offspring, who were ADD1 GlyGly homozygotes (-0.14 +/- 0.06 mm; P = 0.018). CONCLUSIONS: In ADD1 GlyGly homozygotes, the properties of the brachial artery are related to the ADD3 (A386G) polymorphism, but the underlying mechanism needs further clarification.
Mots-clé
Adolescent, Adult, Aged, Aged, 80 and over, Belgium/epidemiology, Brachial Artery/physiopathology, Brachial Artery/ultrasonography, Calmodulin-Binding Proteins/genetics, Carotid Arteries/physiopathology, Carotid Arteries/ultrasonography, Child, Cytoskeletal Proteins, DNA/genetics, European Continental Ancestry Group, Female, Femoral Artery/physiopathology, Femoral Artery/ultrasonography, Genetic Variation, Humans, Hypertension/ethnology, Hypertension/genetics, Male, Middle Aged, Polymerase Chain Reaction, Retrospective Studies, Vascular Resistance/genetics, Young Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
04/08/2009 8:06
Dernière modification de la notice
14/02/2022 7:54
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