Arterial properties in relation to genetic variations in the adducin subunits in a white population.

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Serval ID
serval:BIB_2F27043D31DE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Arterial properties in relation to genetic variations in the adducin subunits in a white population.
Journal
American Journal of Hypertension
Author(s)
Seidlerová J., Staessen J.A., Bochud Murielle, Nawrot T., Casamassima N., Citterio L., Kuznetsova T., Jin Y., Manunta P., Richart T., Struijker-Boudier H.A., Fagard R., Filipovský J., Bianchi G.
ISSN
1879-1905[electronic]
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
22
Number
1
Pages
21-26
Language
english
Abstract
BACKGROUND: Adducin is a membrane skeleton protein, which consists of either alpha- and beta- or alpha- and gamma-subunits. We investigated whether arterial characteristics might be related to the genes encoding ADD1 (Gly460Trp-rs4961), ADD2 (C1797T-rs4984), and ADD3 (IVS11+386A>G-rs3731566). METHODS: We randomly recruited 1,126 Flemish subjects (mean age, 43.8 years; 50.3% women). Using a wall-tracking ultrasound system, we measured the properties of the carotid, femoral, and brachial arteries. We studied multivariate-adjusted phenotype-genotype associations, using a population- and family-based approach. RESULTS: In single-gene analyses, brachial diameter was 0.15 mm (P = 0.0022) larger, and brachial distensibility and cross-sectional compliance were 1.55 x 10(-3)/kPa (P = 0.013) and 0.017 mm(2)/kPa (P = 0.0029) lower in ADD3 AA than ADD3 GG homozygotes with an additive effect of the G allele. In multiple-gene analyses, the association of brachial diameter and distensibility with the ADD3 G allele occurred only in ADD1 GlyGly homozygotes. Otherwise, the associations between the arterial phenotypes in the three vascular beds and the ADD1 or ADD2 polymorphisms were not significant. In family-based analyses, the multivariate-adjusted heritability was 0.52, 0.38, and 0.30 for brachial diameter, distensibility, and cross-sectional compliance, respectively (P < 0.001). There was no evidence for population stratification (0.07 < or = P < or = 0.96). Transmission of the mutated ADD3 G allele was associated with smaller brachial diameter in 342 informative offspring (-0.12 +/- 0.04 mm; P = 0.0085) and in 209 offspring, who were ADD1 GlyGly homozygotes (-0.14 +/- 0.06 mm; P = 0.018). CONCLUSIONS: In ADD1 GlyGly homozygotes, the properties of the brachial artery are related to the ADD3 (A386G) polymorphism, but the underlying mechanism needs further clarification.
Keywords
Adolescent, Adult, Aged, Aged, 80 and over, Belgium/epidemiology, Brachial Artery/physiopathology, Brachial Artery/ultrasonography, Calmodulin-Binding Proteins/genetics, Carotid Arteries/physiopathology, Carotid Arteries/ultrasonography, Child, Cytoskeletal Proteins, DNA/genetics, European Continental Ancestry Group, Female, Femoral Artery/physiopathology, Femoral Artery/ultrasonography, Genetic Variation, Humans, Hypertension/ethnology, Hypertension/genetics, Male, Middle Aged, Polymerase Chain Reaction, Retrospective Studies, Vascular Resistance/genetics, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
04/08/2009 8:06
Last modification date
25/09/2019 6:08
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