Abnormalities of peptide metabolism in Alzheimer disease
Détails
ID Serval
serval:BIB_2EC3C8E10E1A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Abnormalities of peptide metabolism in Alzheimer disease
Périodique
Current Neurovascular Research
ISSN
1567-2026 (Print)
Statut éditorial
Publié
Date de publication
10/2004
Volume
1
Numéro
4
Pages
317-23
Notes
Journal Article
Review --- Old month value: Oct
Review --- Old month value: Oct
Résumé
The steady-state level of peptide hormones represents a balance between their biosynthesis and proteolytic processing by convertases and their catabolism by proteolytic enzymes. Low levels of neuropeptide Y, somatostatin and corticotropin-releasing factor, described in Alzheimer disease (AD), were related to a defect in proteolytic processing of their protein precursors. In contrast the abundance of beta-amyloid peptides, the major protein constituents of senile plaques is likely related to inefficient catabolism. Therefore, attention is mainly focused on convertases that generate active peptides and counter-regulatory proteases that are involved in their catabolism. Some well-described proteases such as NEP are thought to be involved in beta-amyloid catabolism. The search of other possible candidates represents a primary effort in the field. A variety of vascular risk factors such as diabetes, hypertension and arteriosclerosis suggest that the functional vascular defect contributes to AD pathology. It has also been described that beta-amyloid peptides potentiate endothelin-1 induced vasoconstriction. In this review, we will critically evaluate evidence relating proteases implicated in amyloid protein precursor proteolytic processing and beta-amyloid catabolism.
Mots-clé
Alzheimer Disease/*metabolism
Amyloid Precursor Protein Secretases
Amyloid beta-Protein/metabolism
Amyloid beta-Protein Precursor/metabolism
Animals
Aspartic Endopeptidases/classification/metabolism
Endopeptidases
Endothelin-1/pharmacology
Humans
Models, Biological
Peptide Hydrolases/metabolism
Peptides/*metabolism
Pubmed
Web of science
Création de la notice
28/01/2008 11:34
Dernière modification de la notice
20/08/2019 14:13