Abnormalities of peptide metabolism in Alzheimer disease

Details

Serval ID
serval:BIB_2EC3C8E10E1A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Abnormalities of peptide metabolism in Alzheimer disease
Journal
Current Neurovascular Research
Author(s)
Panchal  M., Rholam  M., Brakch  N.
ISSN
1567-2026 (Print)
Publication state
Published
Issued date
10/2004
Volume
1
Number
4
Pages
317-23
Notes
Journal Article
Review --- Old month value: Oct
Abstract
The steady-state level of peptide hormones represents a balance between their biosynthesis and proteolytic processing by convertases and their catabolism by proteolytic enzymes. Low levels of neuropeptide Y, somatostatin and corticotropin-releasing factor, described in Alzheimer disease (AD), were related to a defect in proteolytic processing of their protein precursors. In contrast the abundance of beta-amyloid peptides, the major protein constituents of senile plaques is likely related to inefficient catabolism. Therefore, attention is mainly focused on convertases that generate active peptides and counter-regulatory proteases that are involved in their catabolism. Some well-described proteases such as NEP are thought to be involved in beta-amyloid catabolism. The search of other possible candidates represents a primary effort in the field. A variety of vascular risk factors such as diabetes, hypertension and arteriosclerosis suggest that the functional vascular defect contributes to AD pathology. It has also been described that beta-amyloid peptides potentiate endothelin-1 induced vasoconstriction. In this review, we will critically evaluate evidence relating proteases implicated in amyloid protein precursor proteolytic processing and beta-amyloid catabolism.
Keywords
Alzheimer Disease/*metabolism Amyloid Precursor Protein Secretases Amyloid beta-Protein/metabolism Amyloid beta-Protein Precursor/metabolism Animals Aspartic Endopeptidases/classification/metabolism Endopeptidases Endothelin-1/pharmacology Humans Models, Biological Peptide Hydrolases/metabolism Peptides/*metabolism
Pubmed
Web of science
Create date
28/01/2008 10:34
Last modification date
20/08/2019 13:13
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